Severe relapse after cessation of immunosuppressive therapy in a patient with co‐occurrence of neuromyelitis optica spectrum disorder and Sjögren's syndrome: A case report
Abstract Neuromyelitis optica spectrum disorder (NMOSD) is a group of autoimmune disorders characterized by inflammatory involvement of the optic nerve, spinal cord, and central nervous system. NMOSD is often associated with other autoimmune disorders, including Sjogren's syndrome (SS). While N...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-06-01
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| Series: | Ibrain |
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| Online Access: | https://doi.org/10.1002/ibra.12175 |
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| author | Man‐Min Zhu Zu‐Cai Xu Chang‐Yin Yu Hao Huang |
| author_facet | Man‐Min Zhu Zu‐Cai Xu Chang‐Yin Yu Hao Huang |
| author_sort | Man‐Min Zhu |
| collection | DOAJ |
| description | Abstract Neuromyelitis optica spectrum disorder (NMOSD) is a group of autoimmune disorders characterized by inflammatory involvement of the optic nerve, spinal cord, and central nervous system. NMOSD is often associated with other autoimmune disorders, including Sjogren's syndrome (SS). While NMOSD typically occurs at a peak in young or older individuals, the coexistence of NMOSD and SS in a youngster is rare. Here, we presented a case of a 14‐year‐old girl with NMOSD and SS who responded well to immunosuppressive therapy but experienced a severe relapse after discontinuation of therapy. We described the clinical course of a case over 8 years, underscoring the importance of long‐term treatment for NMOSD and SS. This case, along with the review of relevant literature, will raise awareness of this type of disease and facilitate early diagnosis and treatment to avoid serious sequelae. |
| format | Article |
| id | doaj-art-36284746c8c94c8781fa069ce1604c5e |
| institution | Kabale University |
| issn | 2313-1934 2769-2795 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Ibrain |
| spelling | doaj-art-36284746c8c94c8781fa069ce1604c5e2025-08-20T03:31:19ZengWiley-VCHIbrain2313-19342769-27952025-06-0111226827310.1002/ibra.12175Severe relapse after cessation of immunosuppressive therapy in a patient with co‐occurrence of neuromyelitis optica spectrum disorder and Sjögren's syndrome: A case reportMan‐Min Zhu0Zu‐Cai Xu1Chang‐Yin Yu2Hao Huang3Department of Neurology Affiliated Hospital of Zunyi Medical University Zunyi ChinaDepartment of Neurology Affiliated Hospital of Zunyi Medical University Zunyi ChinaDepartment of Neurology Affiliated Hospital of Zunyi Medical University Zunyi ChinaDepartment of Neurology Affiliated Hospital of Zunyi Medical University Zunyi ChinaAbstract Neuromyelitis optica spectrum disorder (NMOSD) is a group of autoimmune disorders characterized by inflammatory involvement of the optic nerve, spinal cord, and central nervous system. NMOSD is often associated with other autoimmune disorders, including Sjogren's syndrome (SS). While NMOSD typically occurs at a peak in young or older individuals, the coexistence of NMOSD and SS in a youngster is rare. Here, we presented a case of a 14‐year‐old girl with NMOSD and SS who responded well to immunosuppressive therapy but experienced a severe relapse after discontinuation of therapy. We described the clinical course of a case over 8 years, underscoring the importance of long‐term treatment for NMOSD and SS. This case, along with the review of relevant literature, will raise awareness of this type of disease and facilitate early diagnosis and treatment to avoid serious sequelae.https://doi.org/10.1002/ibra.12175immunosuppressive therapyneuromyelitis optica spectrum disorderrelapse childSjogren's syndrome |
| spellingShingle | Man‐Min Zhu Zu‐Cai Xu Chang‐Yin Yu Hao Huang Severe relapse after cessation of immunosuppressive therapy in a patient with co‐occurrence of neuromyelitis optica spectrum disorder and Sjögren's syndrome: A case report Ibrain immunosuppressive therapy neuromyelitis optica spectrum disorder relapse child Sjogren's syndrome |
| title | Severe relapse after cessation of immunosuppressive therapy in a patient with co‐occurrence of neuromyelitis optica spectrum disorder and Sjögren's syndrome: A case report |
| title_full | Severe relapse after cessation of immunosuppressive therapy in a patient with co‐occurrence of neuromyelitis optica spectrum disorder and Sjögren's syndrome: A case report |
| title_fullStr | Severe relapse after cessation of immunosuppressive therapy in a patient with co‐occurrence of neuromyelitis optica spectrum disorder and Sjögren's syndrome: A case report |
| title_full_unstemmed | Severe relapse after cessation of immunosuppressive therapy in a patient with co‐occurrence of neuromyelitis optica spectrum disorder and Sjögren's syndrome: A case report |
| title_short | Severe relapse after cessation of immunosuppressive therapy in a patient with co‐occurrence of neuromyelitis optica spectrum disorder and Sjögren's syndrome: A case report |
| title_sort | severe relapse after cessation of immunosuppressive therapy in a patient with co occurrence of neuromyelitis optica spectrum disorder and sjogren s syndrome a case report |
| topic | immunosuppressive therapy neuromyelitis optica spectrum disorder relapse child Sjogren's syndrome |
| url | https://doi.org/10.1002/ibra.12175 |
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