Correlation analysis of blood bicarbonate and short-term adverse prognosis of acute kidney injury
ObjectiveTo evaluate the relationship between serum bicarbonate （HCO<sub>3</sub><sup>-</sup>） concentration and short-term adverse outcomes in acute kidney injury （AKI） patients.MethodsFrom May 2013 to May 2018， clinical data were retrospectively reviewed for 586 hospitalized...
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Editorial Department of Journal of Clinical Nephrology
2022-12-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.12.005 |
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| author | Li Xian Liu Mei Pan Ling Yang Zhen-hua |
| author_facet | Li Xian Liu Mei Pan Ling Yang Zhen-hua |
| author_sort | Li Xian |
| collection | DOAJ |
| description | ObjectiveTo evaluate the relationship between serum bicarbonate （HCO<sub>3</sub><sup>-</sup>） concentration and short-term adverse outcomes in acute kidney injury （AKI） patients.MethodsFrom May 2013 to May 2018， clinical data were retrospectively reviewed for 586 hospitalized AKI patients. All-cause mortality within 28 days after a diagnosis of AKI was employed as an endpoint of adverse outcome. According to the concentration of blood HCO<sub>3</sub><sup>-</sup>， they were divided into two groups of HCO<sub>3</sub><sup>- </sup>declining （blood HCO<sub>3</sub><sup>-</sup>< 22.0 mmol/L， <italic>n</italic>=279） and HCO<sub>3</sub><sup>- </sup>non-declining （blood HCO<sub>3</sub><sup>-</sup>≥22.0 mmol/L， <italic>n</italic>=307）.ResultsDuring a follow-up period of 28 days， 131 patients （22.4%） died. Kaplan-Meier survival analysis indicated that patients with lower blood HCO<sub>3</sub><sup>-</sup> had a shorter median survival （Log Rank <italic>χ</italic><sup>2</sup>=12.998， <italic>P</italic><0.001）. Multivariate COX regression analysis showed that low blood HCO<sub>3</sub><sup>-</sup> was an independent risk factor for 28-day all-cause mortality in AKI patients after adjusting for age， multiple organ dysfunction syndrome （MODS）， cardiac dysfunction， shock and etiology of AKI （HR=0.917， 95%CI 0.885-0.949， <italic>P</italic><0.001）. Receiver operating characteristic （ROC） curve analysis indicated that the area under the curve （AUC） of blood HCO<sub>3</sub><sup>- </sup>concentration was 0.703 in predicting 28-day mortality of AKI patients （<italic>P</italic><0.001）.ConclusionBlood HCO<sub>3</sub><sup>-</sup> is an important influencing factor of mortality in AKI patients. And lower blood HCO<sub>3</sub><sup>-</sup> has certain clinical value in predicting short-term adverse prognosis of AKI patients. |
| format | Article |
| id | doaj-art-3624601e3a3c4e6fbd0e5106bb9a03c4 |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2022-12-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
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| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-3624601e3a3c4e6fbd0e5106bb9a03c42025-08-20T03:53:07ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902022-12-012299399833236917Correlation analysis of blood bicarbonate and short-term adverse prognosis of acute kidney injuryLi XianLiu MeiPan LingYang Zhen-huaObjectiveTo evaluate the relationship between serum bicarbonate （HCO<sub>3</sub><sup>-</sup>） concentration and short-term adverse outcomes in acute kidney injury （AKI） patients.MethodsFrom May 2013 to May 2018， clinical data were retrospectively reviewed for 586 hospitalized AKI patients. All-cause mortality within 28 days after a diagnosis of AKI was employed as an endpoint of adverse outcome. According to the concentration of blood HCO<sub>3</sub><sup>-</sup>， they were divided into two groups of HCO<sub>3</sub><sup>- </sup>declining （blood HCO<sub>3</sub><sup>-</sup>< 22.0 mmol/L， <italic>n</italic>=279） and HCO<sub>3</sub><sup>- </sup>non-declining （blood HCO<sub>3</sub><sup>-</sup>≥22.0 mmol/L， <italic>n</italic>=307）.ResultsDuring a follow-up period of 28 days， 131 patients （22.4%） died. Kaplan-Meier survival analysis indicated that patients with lower blood HCO<sub>3</sub><sup>-</sup> had a shorter median survival （Log Rank <italic>χ</italic><sup>2</sup>=12.998， <italic>P</italic><0.001）. Multivariate COX regression analysis showed that low blood HCO<sub>3</sub><sup>-</sup> was an independent risk factor for 28-day all-cause mortality in AKI patients after adjusting for age， multiple organ dysfunction syndrome （MODS）， cardiac dysfunction， shock and etiology of AKI （HR=0.917， 95%CI 0.885-0.949， <italic>P</italic><0.001）. Receiver operating characteristic （ROC） curve analysis indicated that the area under the curve （AUC） of blood HCO<sub>3</sub><sup>- </sup>concentration was 0.703 in predicting 28-day mortality of AKI patients （<italic>P</italic><0.001）.ConclusionBlood HCO<sub>3</sub><sup>-</sup> is an important influencing factor of mortality in AKI patients. And lower blood HCO<sub>3</sub><sup>-</sup> has certain clinical value in predicting short-term adverse prognosis of AKI patients.http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.12.005Acute kidney injuryBlood HCO<sub>3</sub><sup>-</sup>All-cause mortalityRisk factor |
| spellingShingle | Li Xian Liu Mei Pan Ling Yang Zhen-hua Correlation analysis of blood bicarbonate and short-term adverse prognosis of acute kidney injury Linchuang shenzangbing zazhi Acute kidney injury Blood HCO<sub>3</sub><sup>-</sup> All-cause mortality Risk factor |
| title | Correlation analysis of blood bicarbonate and short-term adverse prognosis of acute kidney injury |
| title_full | Correlation analysis of blood bicarbonate and short-term adverse prognosis of acute kidney injury |
| title_fullStr | Correlation analysis of blood bicarbonate and short-term adverse prognosis of acute kidney injury |
| title_full_unstemmed | Correlation analysis of blood bicarbonate and short-term adverse prognosis of acute kidney injury |
| title_short | Correlation analysis of blood bicarbonate and short-term adverse prognosis of acute kidney injury |
| title_sort | correlation analysis of blood bicarbonate and short term adverse prognosis of acute kidney injury |
| topic | Acute kidney injury Blood HCO<sub>3</sub><sup>-</sup> All-cause mortality Risk factor |
| url | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.12.005 |
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