Correlation analysis of blood bicarbonate and short-term adverse prognosis of acute kidney injury
ObjectiveTo evaluate the relationship between serum bicarbonate （HCO<sub>3</sub><sup>-</sup>） concentration and short-term adverse outcomes in acute kidney injury （AKI） patients.MethodsFrom May 2013 to May 2018， clinical data were retrospectively reviewed for 586 hospitalized...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2022-12-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.12.005 |
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| Summary: | ObjectiveTo evaluate the relationship between serum bicarbonate （HCO<sub>3</sub><sup>-</sup>） concentration and short-term adverse outcomes in acute kidney injury （AKI） patients.MethodsFrom May 2013 to May 2018， clinical data were retrospectively reviewed for 586 hospitalized AKI patients. All-cause mortality within 28 days after a diagnosis of AKI was employed as an endpoint of adverse outcome. According to the concentration of blood HCO<sub>3</sub><sup>-</sup>， they were divided into two groups of HCO<sub>3</sub><sup>- </sup>declining （blood HCO<sub>3</sub><sup>-</sup>< 22.0 mmol/L， <italic>n</italic>=279） and HCO<sub>3</sub><sup>- </sup>non-declining （blood HCO<sub>3</sub><sup>-</sup>≥22.0 mmol/L， <italic>n</italic>=307）.ResultsDuring a follow-up period of 28 days， 131 patients （22.4%） died. Kaplan-Meier survival analysis indicated that patients with lower blood HCO<sub>3</sub><sup>-</sup> had a shorter median survival （Log Rank <italic>χ</italic><sup>2</sup>=12.998， <italic>P</italic><0.001）. Multivariate COX regression analysis showed that low blood HCO<sub>3</sub><sup>-</sup> was an independent risk factor for 28-day all-cause mortality in AKI patients after adjusting for age， multiple organ dysfunction syndrome （MODS）， cardiac dysfunction， shock and etiology of AKI （HR=0.917， 95%CI 0.885-0.949， <italic>P</italic><0.001）. Receiver operating characteristic （ROC） curve analysis indicated that the area under the curve （AUC） of blood HCO<sub>3</sub><sup>- </sup>concentration was 0.703 in predicting 28-day mortality of AKI patients （<italic>P</italic><0.001）.ConclusionBlood HCO<sub>3</sub><sup>-</sup> is an important influencing factor of mortality in AKI patients. And lower blood HCO<sub>3</sub><sup>-</sup> has certain clinical value in predicting short-term adverse prognosis of AKI patients. |
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| ISSN: | 1671-2390 |