Isolation of a Novel Caprine <i>Eimeria christenseni</i> Strain (GC) in Canary Islands and Analysis of Parasitological, Clinical, and Pathological Findings on Experimentally Infected Goat Kids
<i>Eimeria christenseni</i> is considered among the most pathogenic <i>Eimeria</i> species in goats. The aim of this study was to isolate an <i>E. christenseni</i> strain and to assess its infectivity, pathogenicity, and ability to develop a protective immune resp...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Animals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2615/15/2/139 |
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| Summary: | <i>Eimeria christenseni</i> is considered among the most pathogenic <i>Eimeria</i> species in goats. The aim of this study was to isolate an <i>E. christenseni</i> strain and to assess its infectivity, pathogenicity, and ability to develop a protective immune response. After previous collection of <i>E. christenseni</i>-positive faeces, purification of oocysts, and amplification in donor animals, an experimental infection was carried out. A total of 19 kids were divided into three groups: primary-infected and challenged, challenge control, and uninfected control. Infections were performed orally with 2 × 10<sup>5</sup> sporulated oocysts per animal. Oocyst shedding, clinical signs, and production parameters, in addition to haematological and histopathological features, were monitored. The results showed that the Gran Canaria (GC) <i>E. christenseni</i> strain had similar morphological and biological characteristics to those previously described, but no significant clinical signs were observed despite the high oocyst counts here recorded. The novel strain isolated would therefore be of low pathogenicity but still able to develop significant immunoprotective responses upon challenge infections. Its biological similarities to highly pathogenic species such as <i>Eimeria ninakohlyakimovae</i> and <i>Eimeria arloingi</i> might enable comparative studies aimed at developing alternative strategies for drug treatments, including <i>Eimeria</i> species (strain)-specific vaccination strategies for the efficient control of goat coccidiosis. |
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| ISSN: | 2076-2615 |