Responsive nanoparticles synergize with Curcumin to break the “reactive oxygen Species-Neuroinflammation” vicious cycle, enhancing traumatic brain injury outcomes

Responsive nanoparticles synergize with Curcumin to break the “reactive oxygen Species-Neuroinflammation” vicious cycle, enhancing traumatic brain injury outcomes

Abstract Traumatic brain injury (TBI) disrupts oxygen homeostasis in the brain, leading to excessive reactive oxygen species (ROS) production and dysregulated antioxidant mechanisms, which fail to clear excess ROS. This ROS overload promotes the expression of pro-inflammatory genes, releasing cytoki...

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Bibliographic Details
Main Authors: Xianhua Fu, Yongkang Zhang, Guojie Chen, Guangyao Mao, Jiajia Tang, Jin Xu, Yuhan Han, Honglin Chen, Lianshu Ding
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Nanobiotechnology
Subjects:
Traumatic brain injury
Curcumin
Reactive oxygen species
Neuroinflammation
NF-κB
Online Access:https://doi.org/10.1186/s12951-025-03251-y
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