Responsive nanoparticles synergize with Curcumin to break the “reactive oxygen Species-Neuroinflammation” vicious cycle, enhancing traumatic brain injury outcomes
Abstract Traumatic brain injury (TBI) disrupts oxygen homeostasis in the brain, leading to excessive reactive oxygen species (ROS) production and dysregulated antioxidant mechanisms, which fail to clear excess ROS. This ROS overload promotes the expression of pro-inflammatory genes, releasing cytoki...
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BMC
2025-03-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03251-y |
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| author | Xianhua Fu Yongkang Zhang Guojie Chen Guangyao Mao Jiajia Tang Jin Xu Yuhan Han Honglin Chen Lianshu Ding |
| author_facet | Xianhua Fu Yongkang Zhang Guojie Chen Guangyao Mao Jiajia Tang Jin Xu Yuhan Han Honglin Chen Lianshu Ding |
| author_sort | Xianhua Fu |
| collection | DOAJ |
| description | Abstract Traumatic brain injury (TBI) disrupts oxygen homeostasis in the brain, leading to excessive reactive oxygen species (ROS) production and dysregulated antioxidant mechanisms, which fail to clear excess ROS. This ROS overload promotes the expression of pro-inflammatory genes, releasing cytokines and chemokines and creating a vicious “ROS-neuroinflammation” cycle, making it essential to break this cycle for effective TBI treatment. In this study, we developed cysteine-alanine-glutamine-lysine (CAQK) peptide-modified antioxidant nanoparticles (C-PPS/C) for co-delivery of curcumin (Cur) to modulate oxidative and neuroinflammatory disturbances after TBI. In TBI mice, C-PPS/C nanoparticles accumulated in injured brain regions, where poly (propylene sulfide)120 scavenged ROS, reducing oxidative stress, while Cur release further suppressed ROS and inflammation. C-PPS/C nanoparticles broke the “ROS-neuroinflammation” cycle, protecting the blood-brain barrier (BBB), reducing acute brain edema, and promoting long-term neurological recovery. Further investigation showed that C-PPS/C nanoparticles inhibited the NF-κB pathway, reducing pro-inflammatory gene expression and mitigating inflammation, suggesting a promising approach for TBI treatment. |
| format | Article |
| id | doaj-art-3619bcad44a849eabb7b4d0be41a3f24 |
| institution | OA Journals |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-3619bcad44a849eabb7b4d0be41a3f242025-08-20T01:57:51ZengBMCJournal of Nanobiotechnology1477-31552025-03-0123112210.1186/s12951-025-03251-yResponsive nanoparticles synergize with Curcumin to break the “reactive oxygen Species-Neuroinflammation” vicious cycle, enhancing traumatic brain injury outcomesXianhua Fu0Yongkang Zhang1Guojie Chen2Guangyao Mao3Jiajia Tang4Jin Xu5Yuhan Han6Honglin Chen7Lianshu Ding8Department of Neurosurgery, The Affiliated Huaian NO.1 People’s Hospital of Nanjing Medical UniversityDepartment of Neurosurgery, The Affiliated Hospital of Xuzhou Medical UniversityClinical Laboratory, Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityClinical Laboratory, Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityDepartment of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversityDepartment of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversityBrain Injury Center, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversityDepartment of Neurosurgery, The Affiliated Huaian NO.1 People’s Hospital of Nanjing Medical UniversityAbstract Traumatic brain injury (TBI) disrupts oxygen homeostasis in the brain, leading to excessive reactive oxygen species (ROS) production and dysregulated antioxidant mechanisms, which fail to clear excess ROS. This ROS overload promotes the expression of pro-inflammatory genes, releasing cytokines and chemokines and creating a vicious “ROS-neuroinflammation” cycle, making it essential to break this cycle for effective TBI treatment. In this study, we developed cysteine-alanine-glutamine-lysine (CAQK) peptide-modified antioxidant nanoparticles (C-PPS/C) for co-delivery of curcumin (Cur) to modulate oxidative and neuroinflammatory disturbances after TBI. In TBI mice, C-PPS/C nanoparticles accumulated in injured brain regions, where poly (propylene sulfide)120 scavenged ROS, reducing oxidative stress, while Cur release further suppressed ROS and inflammation. C-PPS/C nanoparticles broke the “ROS-neuroinflammation” cycle, protecting the blood-brain barrier (BBB), reducing acute brain edema, and promoting long-term neurological recovery. Further investigation showed that C-PPS/C nanoparticles inhibited the NF-κB pathway, reducing pro-inflammatory gene expression and mitigating inflammation, suggesting a promising approach for TBI treatment.https://doi.org/10.1186/s12951-025-03251-yTraumatic brain injuryCurcuminReactive oxygen speciesNeuroinflammationNF-κB |
| spellingShingle | Xianhua Fu Yongkang Zhang Guojie Chen Guangyao Mao Jiajia Tang Jin Xu Yuhan Han Honglin Chen Lianshu Ding Responsive nanoparticles synergize with Curcumin to break the “reactive oxygen Species-Neuroinflammation” vicious cycle, enhancing traumatic brain injury outcomes Journal of Nanobiotechnology Traumatic brain injury Curcumin Reactive oxygen species Neuroinflammation NF-κB |
| title | Responsive nanoparticles synergize with Curcumin to break the “reactive oxygen Species-Neuroinflammation” vicious cycle, enhancing traumatic brain injury outcomes |
| title_full | Responsive nanoparticles synergize with Curcumin to break the “reactive oxygen Species-Neuroinflammation” vicious cycle, enhancing traumatic brain injury outcomes |
| title_fullStr | Responsive nanoparticles synergize with Curcumin to break the “reactive oxygen Species-Neuroinflammation” vicious cycle, enhancing traumatic brain injury outcomes |
| title_full_unstemmed | Responsive nanoparticles synergize with Curcumin to break the “reactive oxygen Species-Neuroinflammation” vicious cycle, enhancing traumatic brain injury outcomes |
| title_short | Responsive nanoparticles synergize with Curcumin to break the “reactive oxygen Species-Neuroinflammation” vicious cycle, enhancing traumatic brain injury outcomes |
| title_sort | responsive nanoparticles synergize with curcumin to break the reactive oxygen species neuroinflammation vicious cycle enhancing traumatic brain injury outcomes |
| topic | Traumatic brain injury Curcumin Reactive oxygen species Neuroinflammation NF-κB |
| url | https://doi.org/10.1186/s12951-025-03251-y |
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