Screening of the FDA-approved drug library identifies CCL17 inhibitors that block arthritic pain

Screening of the FDA-approved drug library identifies CCL17 inhibitors that block arthritic pain

Abstract Rheumatoid arthritis (RA) is an inflammatory and destructive autoimmune polyarthritis that causes pain, swelling and deformity in the joints. While clinical trials targeting GM-CSF in RA are showing promise, the potential side effects of anti-GM-CSF therapy highlight the need for identifyin...

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Bibliographic Details
Main Authors: Mahtab Eivazitork, Tanya J. Lupancu, Keith Lim, Yu-Kuan Huang, John A. Hamilton, Kevin M. C. Lee, Adrian A. Achuthan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
CCL17
CCL22
GM-CSF
Arthritis
Pain
Monocytes
Online Access:https://doi.org/10.1038/s41598-025-12191-4
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