ART and the Placenta: An Invited Opinion

It is now well known that there is an increased risk of obstetric complications in pregnancies conceived by assisted reproductive technologies (ART). But is it all the fault of the placenta? And if so, is there anything we can do about it? Current evidence from both human and animal studies does sug...

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Main Author: Gendie E. Lash
Format: Article
Language:English
Published: World Scientific Publishing 2025-06-01
Series:Fertility & Reproduction
Subjects:
Online Access:https://www.worldscientific.com/doi/10.1142/S266131822540002X
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author Gendie E. Lash
author_facet Gendie E. Lash
author_sort Gendie E. Lash
collection DOAJ
description It is now well known that there is an increased risk of obstetric complications in pregnancies conceived by assisted reproductive technologies (ART). But is it all the fault of the placenta? And if so, is there anything we can do about it? Current evidence from both human and animal studies does suggest that there are placentation defects in ART pregnancies, though how these defects are manifested is currently unclear. As to whether anything can be done about it, I think the simple answer at this stage is no. However, an understanding of the different complications that may arise in an ART pregnancy will allow for better screening, monitoring, and early intervention when required in the absence of any curative solutions.
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spelling doaj-art-360b189207c7457dbb4f7a2c32aa47c82025-08-20T02:40:43ZengWorld Scientific PublishingFertility & Reproduction2661-31822661-31742025-06-010702656610.1142/S266131822540002XART and the Placenta: An Invited OpinionGendie E. Lash0Division of Uterine Vascular Biology, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou 510623, ChinaIt is now well known that there is an increased risk of obstetric complications in pregnancies conceived by assisted reproductive technologies (ART). But is it all the fault of the placenta? And if so, is there anything we can do about it? Current evidence from both human and animal studies does suggest that there are placentation defects in ART pregnancies, though how these defects are manifested is currently unclear. As to whether anything can be done about it, I think the simple answer at this stage is no. However, an understanding of the different complications that may arise in an ART pregnancy will allow for better screening, monitoring, and early intervention when required in the absence of any curative solutions.https://www.worldscientific.com/doi/10.1142/S266131822540002XEmbryo ImplantationPlacental InsufficiencyPlacentaEndometriumAssisted Reproductive Techniques
spellingShingle Gendie E. Lash
ART and the Placenta: An Invited Opinion
Fertility & Reproduction
Embryo Implantation
Placental Insufficiency
Placenta
Endometrium
Assisted Reproductive Techniques
title ART and the Placenta: An Invited Opinion
title_full ART and the Placenta: An Invited Opinion
title_fullStr ART and the Placenta: An Invited Opinion
title_full_unstemmed ART and the Placenta: An Invited Opinion
title_short ART and the Placenta: An Invited Opinion
title_sort art and the placenta an invited opinion
topic Embryo Implantation
Placental Insufficiency
Placenta
Endometrium
Assisted Reproductive Techniques
url https://www.worldscientific.com/doi/10.1142/S266131822540002X
work_keys_str_mv AT gendieelash artandtheplacentaaninvitedopinion