Efficacy and safety of transcutaneous auricular vagus nerve stimulation plus pregabalin for radiotherapy-related neuropathic pain in patients with head and neck cancer (RELAX): a phase 2 randomised trialResearch in context

Efficacy and safety of transcutaneous auricular vagus nerve stimulation plus pregabalin for radiotherapy-related neuropathic pain in patients with head and neck cancer (RELAX): a phase 2 randomised trialResearch in context

Summary: Background: Rapid relief of radiotherapy-related neuropathic pain (RRNP) in head and neck cancer (HNC) survivors is challenging when relying solely on pharmacologic treatments, especially in the early stages of medication. Whether transcutaneous auricular vagus nerve stimulation (taVNS) ca...

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Main Authors: Xuzheng Zuo, Yongteng Xu, Shaojian Li, Jingru Jiang, Jinyuan Wang, Yingying Zhu, Dong Pan, Honghong Li, Yanting Chen, Yanmin Chen, Xiaoming Rong, Dong Zheng, Kui Lu, Haiqiang Mai, Mingyuan Chen, Pingyan Chen, Jinpu Li, Charles B. Simone, 2nd, Melvin L.K. Chua, Yi Li, Qingyu Shen, Songhua Xiao, Yamei Tang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:EClinicalMedicine
Subjects:
Radiotherapy
Radiotherapy-related neuropathic pain
Head and neck cancer
Transcutaneous auricular vagus nerve stimulation
Pregabalin
Randomised clinical trial
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537025002779
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