A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor

β-arrestins play pivotal roles in seven transmembrane receptor (7TMR) signalling and trafficking. To study their functional role in regulating specific receptor systems, current research relies mainly on genetic tools, as few pharmacological options are available. To address this issue, we designed...

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Bibliographic Details
Main Authors: Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Pharmacological Research
Subjects:
β-arrestin
vasopressin 2 receptor (V2R)
G protein-coupled receptor (GPCR)
lipopeptide
pepducin
inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825000222
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