Small-vessel-disease-induced white matter damage in occipital lobe epilepsy
BackgroundPeak width of skeletonized mean diffusivity (PSMD) is a novel marker of small vessel disease. This study aimed to investigate the presence of small vessel disease in patients with occipital lobe epilepsy (OLE) using PSMD.MethodsWe enrolled 27 patients newly diagnosed with OLE and included...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1538598/full |
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| author | Jinseung Kim Dong Ah Lee Ho-Joon Lee Kang Min Park |
| author_facet | Jinseung Kim Dong Ah Lee Ho-Joon Lee Kang Min Park |
| author_sort | Jinseung Kim |
| collection | DOAJ |
| description | BackgroundPeak width of skeletonized mean diffusivity (PSMD) is a novel marker of small vessel disease. This study aimed to investigate the presence of small vessel disease in patients with occipital lobe epilepsy (OLE) using PSMD.MethodsWe enrolled 27 patients newly diagnosed with OLE and included 29 healthy controls. The age and sex of the patients and controls were comparable. Diffusion tensor imaging (DTI) was performed using a 3 T MRI scanner. We measured the PSMD based on DTI in several steps, including preprocessing, skeletonization, application of a custom mask, and histogram analysis, using the FSL program. We compared PSMD between patients with OLE and healthy controls. Additionally, we performed a correlation analysis between PSMD and clinical factors in patients with OLE.ResultsOur findings revealed that the patients with OLE exhibited higher PSMD compared to healthy controls (2.459 vs. 2.079 × 10−4 mm2/s, p < 0.001). In addition, PSMD positively correlated with age (r = 0.412, p = 0.032). However, the PSMD of the patients with OLE was not associated with other clinical factors such as age at seizure onset and duration of epilepsy.ConclusionWe demonstrated that patients with OLE had a higher PSMD than healthy controls, indicating evidence of small vessel disease in patients with OLE. This finding also highlights the potential of PSMD as a marker for detecting small vessel diseases in epileptic disorders. |
| format | Article |
| id | doaj-art-360042821a964e0597abe3adc8703499 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-360042821a964e0597abe3adc87034992025-02-11T05:10:26ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-02-011610.3389/fneur.2025.15385981538598Small-vessel-disease-induced white matter damage in occipital lobe epilepsyJinseung Kim0Dong Ah Lee1Ho-Joon Lee2Kang Min Park3Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of KoreaDepartment of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of KoreaDepartment of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of KoreaDepartment of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of KoreaBackgroundPeak width of skeletonized mean diffusivity (PSMD) is a novel marker of small vessel disease. This study aimed to investigate the presence of small vessel disease in patients with occipital lobe epilepsy (OLE) using PSMD.MethodsWe enrolled 27 patients newly diagnosed with OLE and included 29 healthy controls. The age and sex of the patients and controls were comparable. Diffusion tensor imaging (DTI) was performed using a 3 T MRI scanner. We measured the PSMD based on DTI in several steps, including preprocessing, skeletonization, application of a custom mask, and histogram analysis, using the FSL program. We compared PSMD between patients with OLE and healthy controls. Additionally, we performed a correlation analysis between PSMD and clinical factors in patients with OLE.ResultsOur findings revealed that the patients with OLE exhibited higher PSMD compared to healthy controls (2.459 vs. 2.079 × 10−4 mm2/s, p < 0.001). In addition, PSMD positively correlated with age (r = 0.412, p = 0.032). However, the PSMD of the patients with OLE was not associated with other clinical factors such as age at seizure onset and duration of epilepsy.ConclusionWe demonstrated that patients with OLE had a higher PSMD than healthy controls, indicating evidence of small vessel disease in patients with OLE. This finding also highlights the potential of PSMD as a marker for detecting small vessel diseases in epileptic disorders.https://www.frontiersin.org/articles/10.3389/fneur.2025.1538598/fullepilepsydiffusion tensor imagingcerebral small vessel diseaseswhite matterneuroimaging |
| spellingShingle | Jinseung Kim Dong Ah Lee Ho-Joon Lee Kang Min Park Small-vessel-disease-induced white matter damage in occipital lobe epilepsy Frontiers in Neurology epilepsy diffusion tensor imaging cerebral small vessel diseases white matter neuroimaging |
| title | Small-vessel-disease-induced white matter damage in occipital lobe epilepsy |
| title_full | Small-vessel-disease-induced white matter damage in occipital lobe epilepsy |
| title_fullStr | Small-vessel-disease-induced white matter damage in occipital lobe epilepsy |
| title_full_unstemmed | Small-vessel-disease-induced white matter damage in occipital lobe epilepsy |
| title_short | Small-vessel-disease-induced white matter damage in occipital lobe epilepsy |
| title_sort | small vessel disease induced white matter damage in occipital lobe epilepsy |
| topic | epilepsy diffusion tensor imaging cerebral small vessel diseases white matter neuroimaging |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1538598/full |
| work_keys_str_mv | AT jinseungkim smallvesseldiseaseinducedwhitematterdamageinoccipitallobeepilepsy AT dongahlee smallvesseldiseaseinducedwhitematterdamageinoccipitallobeepilepsy AT hojoonlee smallvesseldiseaseinducedwhitematterdamageinoccipitallobeepilepsy AT kangminpark smallvesseldiseaseinducedwhitematterdamageinoccipitallobeepilepsy |