Bioactive natural alkaloid 6−Methoxydihydrosanguinarine exerts anti−tumor effects in hepatocellular carcinoma cells via ferroptosis

Bioactive natural alkaloid 6−Methoxydihydrosanguinarine exerts anti−tumor effects in hepatocellular carcinoma cells via ferroptosis

IntroductionFerroptosis is a form of regulated cell death driven by the accumulation of iron–dependent lipid peroxides, and ferroptosis–mediated cancer therapy has gained considerable attention. Despite emerging evidence that ferroptosis induction effectively suppresses hepatocellular carcinoma (HCC...

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Bibliographic Details
Main Authors: Linfen Han, Chengchang Gao, Xiaorui Jin, Yingping Li, Liangjie Chen, Donglin Li, Qinqin Deng, Xueli Bian
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
6-methoxydihydrosanguinarine
HCC
ROS
ferroptosis
GPX4
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1500461/full
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