Dendritic cell effector mechanisms and tumor immune microenvironment infiltration define TLR8 modulation and PD-1 blockade

The potent immunostimulatory effects of toll-like receptor 8 (TLR8) agonism in combination with PD-1 blockade have resulted in various preclinical investigations, yet the mechanism of action in humans remains unknown. To decipher the combinatory mode of action of TLR8 agonism and PD-1 blockade, we e...

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Bibliographic Details
Main Authors:	Daniel A. Ruiz-Torres, Jillian F. Wise, Brian Yinge Zhao, Joao Paulo Oliveira-Costa, Sara Cavallaro, Peter M. Sadow, Jacy Fang, Osman Yilmaz, Amar Patel, Christopher Loosbroock, Moshe Sade-Feldman, Daniel L. Faden, Shannon L. Stott
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-12-01
Series:	Frontiers in Immunology
Subjects:	immune response dendritic cells checkpoint blockade immunotherapy cancer
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1440530/full
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Dendritic cell effector mechanisms and tumor immune microenvironment infiltration define TLR8 modulation and PD-1 blockade

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