Validation of new diagnostic indices to simplify hyponatremia therapy assessment in patients on thiazide diuretics: study protocol of a randomized, controlled, parallel-group trial (THAT-Study)

Validation of new diagnostic indices to simplify hyponatremia therapy assessment in patients on thiazide diuretics: study protocol of a randomized, controlled, parallel-group trial (THAT-Study)

Abstract Background Thiazide or thiazide-like diuretics associated hyponatremia (TAH) has a high prevalence in hospitalized patients. Patients might present either with hypovolemic hyponatremia due to volume loss as a diuretic effect of thiazide or with a thiazide-induced syndrome of inadequate anti...

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Bibliographic Details
Main Authors: Karin Vogt, David Widmer, Mark Kirsch, Mirjam Christ-Crain, Laura Potasso
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Trials
Subjects:
Sodium
Thiazide-associated hyponatremia
Volume status
Hydration status
ASID
Stewart model
Online Access:https://doi.org/10.1186/s13063-025-08925-4
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