Effect of Antiplatelet Therapy on Acute Respiratory Distress Syndrome and Mortality in Critically Ill Patients: A Meta-Analysis.
<h4>Background</h4>Antiplatelet agents are commonly used for cardiovascular diseases, but their pleiotropic effects in critically ill patients are controversial. We therefore performed a meta-analysis of cohort studies to investigate the effect of antiplatelet therapy in the critically i...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0154754&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849723462183026688 |
|---|---|
| author | Lijun Wang Heng Li Xiaofei Gu Zhen Wang Su Liu Liyong Chen |
| author_facet | Lijun Wang Heng Li Xiaofei Gu Zhen Wang Su Liu Liyong Chen |
| author_sort | Lijun Wang |
| collection | DOAJ |
| description | <h4>Background</h4>Antiplatelet agents are commonly used for cardiovascular diseases, but their pleiotropic effects in critically ill patients are controversial. We therefore performed a meta-analysis of cohort studies to investigate the effect of antiplatelet therapy in the critically ill.<h4>Methods</h4>Nine cohort studies, retrieved from PubMed and Embase before November 2015, involving 14,612 critically ill patients and 4765 cases of antiplatelet users, were meta-analysed. The main outcome was hospital or 30-day mortality. Secondary outcome was acute respiratory distress syndrome (ARDS) or acute lung injury (ALI). Random- or fixed-effect models were taken for quantitative synthesis of the data.<h4>Results</h4>Antiplatelet therapy was associated with decreased mortality (odds ratio (OR) 0.61; 95% confidence interval (CI), 0.52-0.71; I2 = 0%; P <0. 001) and ARDS/ALI (OR 0.64; 95% CI, 0.50-0.82; I2 = 0%; P <0. 001). In every stratum of subgroups, similar findings on mortality reduction were consistently observed in critically ill patients.<h4>Conclusions</h4>Antiplatelet therapy is associated with reduced mortality and lower incidence of ARDS/ALI in critically ill patients, particularly those with predisposing conditions such as high-risk surgery, trauma, pneumonia, and sepsis. However, it remains unclear whether similar findings can be observed in the unselected and broad population with critical illness. |
| format | Article |
| id | doaj-art-35f41c80f8f84dee9acf8197f329038c |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-35f41c80f8f84dee9acf8197f329038c2025-08-20T03:11:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01115e015475410.1371/journal.pone.0154754Effect of Antiplatelet Therapy on Acute Respiratory Distress Syndrome and Mortality in Critically Ill Patients: A Meta-Analysis.Lijun WangHeng LiXiaofei GuZhen WangSu LiuLiyong Chen<h4>Background</h4>Antiplatelet agents are commonly used for cardiovascular diseases, but their pleiotropic effects in critically ill patients are controversial. We therefore performed a meta-analysis of cohort studies to investigate the effect of antiplatelet therapy in the critically ill.<h4>Methods</h4>Nine cohort studies, retrieved from PubMed and Embase before November 2015, involving 14,612 critically ill patients and 4765 cases of antiplatelet users, were meta-analysed. The main outcome was hospital or 30-day mortality. Secondary outcome was acute respiratory distress syndrome (ARDS) or acute lung injury (ALI). Random- or fixed-effect models were taken for quantitative synthesis of the data.<h4>Results</h4>Antiplatelet therapy was associated with decreased mortality (odds ratio (OR) 0.61; 95% confidence interval (CI), 0.52-0.71; I2 = 0%; P <0. 001) and ARDS/ALI (OR 0.64; 95% CI, 0.50-0.82; I2 = 0%; P <0. 001). In every stratum of subgroups, similar findings on mortality reduction were consistently observed in critically ill patients.<h4>Conclusions</h4>Antiplatelet therapy is associated with reduced mortality and lower incidence of ARDS/ALI in critically ill patients, particularly those with predisposing conditions such as high-risk surgery, trauma, pneumonia, and sepsis. However, it remains unclear whether similar findings can be observed in the unselected and broad population with critical illness.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0154754&type=printable |
| spellingShingle | Lijun Wang Heng Li Xiaofei Gu Zhen Wang Su Liu Liyong Chen Effect of Antiplatelet Therapy on Acute Respiratory Distress Syndrome and Mortality in Critically Ill Patients: A Meta-Analysis. PLoS ONE |
| title | Effect of Antiplatelet Therapy on Acute Respiratory Distress Syndrome and Mortality in Critically Ill Patients: A Meta-Analysis. |
| title_full | Effect of Antiplatelet Therapy on Acute Respiratory Distress Syndrome and Mortality in Critically Ill Patients: A Meta-Analysis. |
| title_fullStr | Effect of Antiplatelet Therapy on Acute Respiratory Distress Syndrome and Mortality in Critically Ill Patients: A Meta-Analysis. |
| title_full_unstemmed | Effect of Antiplatelet Therapy on Acute Respiratory Distress Syndrome and Mortality in Critically Ill Patients: A Meta-Analysis. |
| title_short | Effect of Antiplatelet Therapy on Acute Respiratory Distress Syndrome and Mortality in Critically Ill Patients: A Meta-Analysis. |
| title_sort | effect of antiplatelet therapy on acute respiratory distress syndrome and mortality in critically ill patients a meta analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0154754&type=printable |
| work_keys_str_mv | AT lijunwang effectofantiplatelettherapyonacuterespiratorydistresssyndromeandmortalityincriticallyillpatientsametaanalysis AT hengli effectofantiplatelettherapyonacuterespiratorydistresssyndromeandmortalityincriticallyillpatientsametaanalysis AT xiaofeigu effectofantiplatelettherapyonacuterespiratorydistresssyndromeandmortalityincriticallyillpatientsametaanalysis AT zhenwang effectofantiplatelettherapyonacuterespiratorydistresssyndromeandmortalityincriticallyillpatientsametaanalysis AT suliu effectofantiplatelettherapyonacuterespiratorydistresssyndromeandmortalityincriticallyillpatientsametaanalysis AT liyongchen effectofantiplatelettherapyonacuterespiratorydistresssyndromeandmortalityincriticallyillpatientsametaanalysis |