Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM
Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/2452853 |
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| _version_ | 1850216602755137536 |
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| author | Marwan A. Ahmed George L. Muntingh Paul Rheeder |
| author_facet | Marwan A. Ahmed George L. Muntingh Paul Rheeder |
| author_sort | Marwan A. Ahmed |
| collection | DOAJ |
| description | Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of the topic and the inconsistency of the results warrant consideration of topic-specific perspectives for better understanding of the available evidence and more appropriate design of future studies. |
| format | Article |
| id | doaj-art-35f3c6d0a7eb44b7be26861276e42838 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-35f3c6d0a7eb44b7be26861276e428382025-08-20T02:08:15ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/24528532452853Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DMMarwan A. Ahmed0George L. Muntingh1Paul Rheeder2Department of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria, South AfricaDepartment of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria, South AfricaDepartment of Internal Medicine, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South AfricaPeripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of the topic and the inconsistency of the results warrant consideration of topic-specific perspectives for better understanding of the available evidence and more appropriate design of future studies.http://dx.doi.org/10.1155/2017/2452853 |
| spellingShingle | Marwan A. Ahmed George L. Muntingh Paul Rheeder Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM International Journal of Endocrinology |
| title | Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM |
| title_full | Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM |
| title_fullStr | Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM |
| title_full_unstemmed | Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM |
| title_short | Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM |
| title_sort | perspectives on peripheral neuropathy as a consequence of metformin induced vitamin b12 deficiency in t2dm |
| url | http://dx.doi.org/10.1155/2017/2452853 |
| work_keys_str_mv | AT marwanaahmed perspectivesonperipheralneuropathyasaconsequenceofmetformininducedvitaminb12deficiencyint2dm AT georgelmuntingh perspectivesonperipheralneuropathyasaconsequenceofmetformininducedvitaminb12deficiencyint2dm AT paulrheeder perspectivesonperipheralneuropathyasaconsequenceofmetformininducedvitaminb12deficiencyint2dm |