Modification of Specific Regions of the Human Cytomegalovirus Genome During in Vitro Passage

Different regions of the human cytomegalovirus strain AD-169 DNA molecule were tested for stability using cloned Hind III fragments. Results indicate that insertion, deletion and/or rearrangement of nucleotide sequences occur at a relatively high frequency in all parts of the human cytomegalovirus g...

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Main Authors: Claude Hamelin, Michel Dion
Format: Article
Language:English
Published: Wiley 1990-01-01
Series:Canadian Journal of Infectious Diseases
Online Access:http://dx.doi.org/10.1155/1990/185934
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author Claude Hamelin
Michel Dion
author_facet Claude Hamelin
Michel Dion
author_sort Claude Hamelin
collection DOAJ
description Different regions of the human cytomegalovirus strain AD-169 DNA molecule were tested for stability using cloned Hind III fragments. Results indicate that insertion, deletion and/or rearrangement of nucleotide sequences occur at a relatively high frequency in all parts of the human cytomegalovirus genome during in vitro passage.
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publisher Wiley
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series Canadian Journal of Infectious Diseases
spelling doaj-art-35ef54c33d4644b89473e54ec4e939902025-08-20T03:55:08ZengWileyCanadian Journal of Infectious Diseases1180-23321990-01-0112485010.1155/1990/185934Modification of Specific Regions of the Human Cytomegalovirus Genome During in Vitro PassageClaude Hamelin0Michel Dion1Centre de recherche en virologie, Institut Armand-Frappier, Laval-des-Rapides, Quebec, CanadaCentre de recherche en virologie, Institut Armand-Frappier, Laval-des-Rapides, Quebec, CanadaDifferent regions of the human cytomegalovirus strain AD-169 DNA molecule were tested for stability using cloned Hind III fragments. Results indicate that insertion, deletion and/or rearrangement of nucleotide sequences occur at a relatively high frequency in all parts of the human cytomegalovirus genome during in vitro passage.http://dx.doi.org/10.1155/1990/185934
spellingShingle Claude Hamelin
Michel Dion
Modification of Specific Regions of the Human Cytomegalovirus Genome During in Vitro Passage
Canadian Journal of Infectious Diseases
title Modification of Specific Regions of the Human Cytomegalovirus Genome During in Vitro Passage
title_full Modification of Specific Regions of the Human Cytomegalovirus Genome During in Vitro Passage
title_fullStr Modification of Specific Regions of the Human Cytomegalovirus Genome During in Vitro Passage
title_full_unstemmed Modification of Specific Regions of the Human Cytomegalovirus Genome During in Vitro Passage
title_short Modification of Specific Regions of the Human Cytomegalovirus Genome During in Vitro Passage
title_sort modification of specific regions of the human cytomegalovirus genome during in vitro passage
url http://dx.doi.org/10.1155/1990/185934
work_keys_str_mv AT claudehamelin modificationofspecificregionsofthehumancytomegalovirusgenomeduringinvitropassage
AT micheldion modificationofspecificregionsofthehumancytomegalovirusgenomeduringinvitropassage