NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis

NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis

Abstract In eukaryotes, the nucleocytoplasmic export of bulk poly(A)+-mRNAs through the nuclear pore complex is mediated by the ubiquitously expressed NXT1-NXF1 heterodimer. In humans, NXT1 has an X-chromosomal paralog, NXT2, which exhibits testis-enriched expression, suggesting a role in spermatoge...

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Main Authors: Ann-Kristin Dicke, Ammar Ahmedani, Lin Ma, Leonie Herrmann, Godfried W. van der Heijden, Sophie A. Koser, Claudia Krallmann, Oguzhan Kalyon, Miguel J. Xavier, Joris A. Veltman, Sabine Kliesch, Nina Neuhaus, Noora Kotaja, Frank Tüttelmann, Birgit Stallmeyer
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61463-0
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