Role of blood Krebs von Lungen-6 in predicting acute exacerbation in patients with idiopathic pulmonary fibrosis.
<h4>Background</h4>This study evaluated the role of blood Krebs von den Lungen-6 (KL-6) in predicting acute exacerbation (AE) in patients with idiopathic pulmonary fibrosis (IPF).<h4>Methods</h4>From April 2018 to March 2023, clinical data of 233 IPF patients with baseline an...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0323784 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850127294709891072 |
|---|---|
| author | Eun Jun Choe Ji Hoon Jang Jin Han Park So Young Jung Minyoung Her Jae Ha Lee |
| author_facet | Eun Jun Choe Ji Hoon Jang Jin Han Park So Young Jung Minyoung Her Jae Ha Lee |
| author_sort | Eun Jun Choe |
| collection | DOAJ |
| description | <h4>Background</h4>This study evaluated the role of blood Krebs von den Lungen-6 (KL-6) in predicting acute exacerbation (AE) in patients with idiopathic pulmonary fibrosis (IPF).<h4>Methods</h4>From April 2018 to March 2023, clinical data of 233 IPF patients with baseline and follow-up KL-6 values at Haeundae Paik Hospital were retrospectively analyzed. AE was defined following the criteria proposed by Collard et al. in 2016.<h4>Results</h4>The mean age was 71.8 years; 79% were male. During follow-up (median: 18.7 months), 33 (14.2%) patients experienced AE. Throughout the entire period from baseline, KL-6 values were higher in the AE group compared to the non-AE group (P < 0.001), and the patterns of change over time also showed significant differences between both groups (P < 0.001). The KL-6 values in the post-exacerbation phase were higher than those in the pre-exacerbation phase among the AE group (P = 0.004). The AE group showed lower 1-year (86.4% vs. 95.9%) and 3-year (50.2% vs. 91.4%) survival rates compared to the non-AE group (P < 0.001). The occurrence of AE (hazard ratio (HR) 74.09, 95% confidence interval (CI) 31.97-171.7, P < 0.001) and higher lactate dehydrogenase (HR 1.02, 95% CI: 1.01-1.02, P < 0.001) were independently associated with mortality in patients with IPF.<h4>Conclusions</h4>Our data suggest that the trend in changes in KL-6 values may be utilized as a tool for predicting AE-IPF. Further research is needed to establish the clinical significance of changes in KL-6 for predicting AE-IPF and to validate the cut-off values for prediction. |
| format | Article |
| id | doaj-art-35eeb04824b445a8ad80affd580fa3a5 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-35eeb04824b445a8ad80affd580fa3a52025-08-20T02:33:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01205e032378410.1371/journal.pone.0323784Role of blood Krebs von Lungen-6 in predicting acute exacerbation in patients with idiopathic pulmonary fibrosis.Eun Jun ChoeJi Hoon JangJin Han ParkSo Young JungMinyoung HerJae Ha Lee<h4>Background</h4>This study evaluated the role of blood Krebs von den Lungen-6 (KL-6) in predicting acute exacerbation (AE) in patients with idiopathic pulmonary fibrosis (IPF).<h4>Methods</h4>From April 2018 to March 2023, clinical data of 233 IPF patients with baseline and follow-up KL-6 values at Haeundae Paik Hospital were retrospectively analyzed. AE was defined following the criteria proposed by Collard et al. in 2016.<h4>Results</h4>The mean age was 71.8 years; 79% were male. During follow-up (median: 18.7 months), 33 (14.2%) patients experienced AE. Throughout the entire period from baseline, KL-6 values were higher in the AE group compared to the non-AE group (P < 0.001), and the patterns of change over time also showed significant differences between both groups (P < 0.001). The KL-6 values in the post-exacerbation phase were higher than those in the pre-exacerbation phase among the AE group (P = 0.004). The AE group showed lower 1-year (86.4% vs. 95.9%) and 3-year (50.2% vs. 91.4%) survival rates compared to the non-AE group (P < 0.001). The occurrence of AE (hazard ratio (HR) 74.09, 95% confidence interval (CI) 31.97-171.7, P < 0.001) and higher lactate dehydrogenase (HR 1.02, 95% CI: 1.01-1.02, P < 0.001) were independently associated with mortality in patients with IPF.<h4>Conclusions</h4>Our data suggest that the trend in changes in KL-6 values may be utilized as a tool for predicting AE-IPF. Further research is needed to establish the clinical significance of changes in KL-6 for predicting AE-IPF and to validate the cut-off values for prediction.https://doi.org/10.1371/journal.pone.0323784 |
| spellingShingle | Eun Jun Choe Ji Hoon Jang Jin Han Park So Young Jung Minyoung Her Jae Ha Lee Role of blood Krebs von Lungen-6 in predicting acute exacerbation in patients with idiopathic pulmonary fibrosis. PLoS ONE |
| title | Role of blood Krebs von Lungen-6 in predicting acute exacerbation in patients with idiopathic pulmonary fibrosis. |
| title_full | Role of blood Krebs von Lungen-6 in predicting acute exacerbation in patients with idiopathic pulmonary fibrosis. |
| title_fullStr | Role of blood Krebs von Lungen-6 in predicting acute exacerbation in patients with idiopathic pulmonary fibrosis. |
| title_full_unstemmed | Role of blood Krebs von Lungen-6 in predicting acute exacerbation in patients with idiopathic pulmonary fibrosis. |
| title_short | Role of blood Krebs von Lungen-6 in predicting acute exacerbation in patients with idiopathic pulmonary fibrosis. |
| title_sort | role of blood krebs von lungen 6 in predicting acute exacerbation in patients with idiopathic pulmonary fibrosis |
| url | https://doi.org/10.1371/journal.pone.0323784 |
| work_keys_str_mv | AT eunjunchoe roleofbloodkrebsvonlungen6inpredictingacuteexacerbationinpatientswithidiopathicpulmonaryfibrosis AT jihoonjang roleofbloodkrebsvonlungen6inpredictingacuteexacerbationinpatientswithidiopathicpulmonaryfibrosis AT jinhanpark roleofbloodkrebsvonlungen6inpredictingacuteexacerbationinpatientswithidiopathicpulmonaryfibrosis AT soyoungjung roleofbloodkrebsvonlungen6inpredictingacuteexacerbationinpatientswithidiopathicpulmonaryfibrosis AT minyoungher roleofbloodkrebsvonlungen6inpredictingacuteexacerbationinpatientswithidiopathicpulmonaryfibrosis AT jaehalee roleofbloodkrebsvonlungen6inpredictingacuteexacerbationinpatientswithidiopathicpulmonaryfibrosis |