Molecular Imaging: A Promising Tool to Monitor Islet Transplantation
Replacement of insulin production by pancreatic islet transplantation has great potential as a therapy for type 1 diabetes mellitus. At present, the lack of an effective approach to islet grafts assessment limits the success of this treatment. The development of molecular imaging techniques has the...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2011/202915 |
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| _version_ | 1849306227921649664 |
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| author | Ping Wang Zdravka Medarova Anna Moore |
| author_facet | Ping Wang Zdravka Medarova Anna Moore |
| author_sort | Ping Wang |
| collection | DOAJ |
| description | Replacement of insulin production by pancreatic islet transplantation has great potential as a therapy for type 1 diabetes mellitus. At present, the lack of an effective approach to islet grafts assessment limits the success of this treatment. The development of molecular imaging techniques has the potential to fulfill the goal of real-time noninvasive monitoring of the functional status and viability of the islet grafts. We review the application of a variety of imaging modalities for detecting endogenous and transplanted beta-cell mass. The review also explores the various molecular imaging strategies for assessing islet delivery, the metabolic effects on the islet grafts as well as detection of immunorejection. Here, we highlight the use of combined imaging and therapeutic interventions in islet transplantation and the in vivo monitoring of stem cells differentiation into insulin-producing cells. |
| format | Article |
| id | doaj-art-35edee21e31b4d7ba8a6a5682f17eb26 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-35edee21e31b4d7ba8a6a5682f17eb262025-08-20T03:55:08ZengWileyJournal of Transplantation2090-00072090-00152011-01-01201110.1155/2011/202915202915Molecular Imaging: A Promising Tool to Monitor Islet TransplantationPing Wang0Zdravka Medarova1Anna Moore2Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USAMolecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USAMolecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USAReplacement of insulin production by pancreatic islet transplantation has great potential as a therapy for type 1 diabetes mellitus. At present, the lack of an effective approach to islet grafts assessment limits the success of this treatment. The development of molecular imaging techniques has the potential to fulfill the goal of real-time noninvasive monitoring of the functional status and viability of the islet grafts. We review the application of a variety of imaging modalities for detecting endogenous and transplanted beta-cell mass. The review also explores the various molecular imaging strategies for assessing islet delivery, the metabolic effects on the islet grafts as well as detection of immunorejection. Here, we highlight the use of combined imaging and therapeutic interventions in islet transplantation and the in vivo monitoring of stem cells differentiation into insulin-producing cells.http://dx.doi.org/10.1155/2011/202915 |
| spellingShingle | Ping Wang Zdravka Medarova Anna Moore Molecular Imaging: A Promising Tool to Monitor Islet Transplantation Journal of Transplantation |
| title | Molecular Imaging: A Promising Tool to Monitor Islet Transplantation |
| title_full | Molecular Imaging: A Promising Tool to Monitor Islet Transplantation |
| title_fullStr | Molecular Imaging: A Promising Tool to Monitor Islet Transplantation |
| title_full_unstemmed | Molecular Imaging: A Promising Tool to Monitor Islet Transplantation |
| title_short | Molecular Imaging: A Promising Tool to Monitor Islet Transplantation |
| title_sort | molecular imaging a promising tool to monitor islet transplantation |
| url | http://dx.doi.org/10.1155/2011/202915 |
| work_keys_str_mv | AT pingwang molecularimagingapromisingtooltomonitorislettransplantation AT zdravkamedarova molecularimagingapromisingtooltomonitorislettransplantation AT annamoore molecularimagingapromisingtooltomonitorislettransplantation |