Structural and functional alterations of the hippocampal subfields in T2DM with mild cognitive impairment and insulin resistance: A prospective study
Abstract Background Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR) and is often accompanied by mild cognitive impairment (MCI). The detrimental effects of T2DM and IR on the hippocampus have been extensively demonstrated. Few studies have examined the effects of IR on st...
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Wiley
2024-11-01
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| Series: | Journal of Diabetes |
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| Online Access: | https://doi.org/10.1111/1753-0407.70029 |
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| author | Chen Yang Huiyan Zhang Zihan Ma Yanjun Fan Yanan Xu Jian Tan Jing Tian Jiancang Cao Wenwen Zhang Gang Huang Lianping Zhao |
| author_facet | Chen Yang Huiyan Zhang Zihan Ma Yanjun Fan Yanan Xu Jian Tan Jing Tian Jiancang Cao Wenwen Zhang Gang Huang Lianping Zhao |
| author_sort | Chen Yang |
| collection | DOAJ |
| description | Abstract Background Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR) and is often accompanied by mild cognitive impairment (MCI). The detrimental effects of T2DM and IR on the hippocampus have been extensively demonstrated. Few studies have examined the effects of IR on structure and function of hippocampal subfields in T2DM‐MCI patients. Method A total of 104 T2DM patients were recruited in this prospective study and divided into four groups (T2DM‐MCI‐higherIR, n = 17; T2DM‐MCI‐lowerIR, n = 32; T2DM‐nonMCI‐higherIR, n = 19; T2DM‐nonMCI‐lowerIR, n = 36). Structure and function MRI data were captured. Clinical variables and neuropsychological scores were determined for all participants. Hippocampal subfield volume and functional connectivity were compared among four groups. Partial correlation analysis was performed between imaging indicators, clinical variables, and neuropsychological scores in all patients. Results T2DM‐MCI‐higher IR group had the smallest volumes of bilateral hippocampal tail, right subiculum‐body, right GC‐ML‐DG‐body, and right CA4‐body. IR in right hippocampal tail, right subiculum‐body, and right GC‐ML‐DG‐body exerted main effect. Furthermore, elevated functional connectivity was found between right subiculum‐body and bilateral dorsolateral prefrontal cortex and right anterior cingulate–medial prefrontal cortex. Hippocampal subfield volume positively correlates with total cholesterol and triglycerides and negatively correlates with fasting insulin. Conclusion The present study found that T2DM‐MCI patients have structural and functional alterations in hippocampal subfields, and IR is a negative factor influencing the alteration of hippocampal subfields volume. These findings support the importance of IR in T2DM‐MCI patients and might be potential neuroimaging biomarkers of cerebral impairment in T2DM‐MCI patients. |
| format | Article |
| id | doaj-art-35ebe905314b48179100bd4bd8fd7cbf |
| institution | OA Journals |
| issn | 1753-0393 1753-0407 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
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| series | Journal of Diabetes |
| spelling | doaj-art-35ebe905314b48179100bd4bd8fd7cbf2025-08-20T02:23:09ZengWileyJournal of Diabetes1753-03931753-04072024-11-011611n/an/a10.1111/1753-0407.70029Structural and functional alterations of the hippocampal subfields in T2DM with mild cognitive impairment and insulin resistance: A prospective studyChen Yang0Huiyan Zhang1Zihan Ma2Yanjun Fan3Yanan Xu4Jian Tan5Jing Tian6Jiancang Cao7Wenwen Zhang8Gang Huang9Lianping Zhao10The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital) Gansu University of Chinese Medicine Lanzhou ChinaSchool of Clinical Medicine Ningxia Medical University Yinchuan ChinaThe First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital) Gansu University of Chinese Medicine Lanzhou ChinaThe First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital) Gansu University of Chinese Medicine Lanzhou ChinaThe First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital) Gansu University of Chinese Medicine Lanzhou ChinaThe First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital) Gansu University of Chinese Medicine Lanzhou ChinaDepartment of Radiology Gansu Provincial Hospital Lanzhou ChinaDepartment of Radiology Gansu Provincial Hospital Lanzhou ChinaDepartment of Radiology Gansu Provincial Hospital Lanzhou ChinaDepartment of Radiology Gansu Provincial Hospital Lanzhou ChinaDepartment of Radiology Gansu Provincial Hospital Lanzhou ChinaAbstract Background Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR) and is often accompanied by mild cognitive impairment (MCI). The detrimental effects of T2DM and IR on the hippocampus have been extensively demonstrated. Few studies have examined the effects of IR on structure and function of hippocampal subfields in T2DM‐MCI patients. Method A total of 104 T2DM patients were recruited in this prospective study and divided into four groups (T2DM‐MCI‐higherIR, n = 17; T2DM‐MCI‐lowerIR, n = 32; T2DM‐nonMCI‐higherIR, n = 19; T2DM‐nonMCI‐lowerIR, n = 36). Structure and function MRI data were captured. Clinical variables and neuropsychological scores were determined for all participants. Hippocampal subfield volume and functional connectivity were compared among four groups. Partial correlation analysis was performed between imaging indicators, clinical variables, and neuropsychological scores in all patients. Results T2DM‐MCI‐higher IR group had the smallest volumes of bilateral hippocampal tail, right subiculum‐body, right GC‐ML‐DG‐body, and right CA4‐body. IR in right hippocampal tail, right subiculum‐body, and right GC‐ML‐DG‐body exerted main effect. Furthermore, elevated functional connectivity was found between right subiculum‐body and bilateral dorsolateral prefrontal cortex and right anterior cingulate–medial prefrontal cortex. Hippocampal subfield volume positively correlates with total cholesterol and triglycerides and negatively correlates with fasting insulin. Conclusion The present study found that T2DM‐MCI patients have structural and functional alterations in hippocampal subfields, and IR is a negative factor influencing the alteration of hippocampal subfields volume. These findings support the importance of IR in T2DM‐MCI patients and might be potential neuroimaging biomarkers of cerebral impairment in T2DM‐MCI patients.https://doi.org/10.1111/1753-0407.70029hippocampusinsulin resistancemagnetic resonance imagingmild cognitive impairmenttype 2 diabetes mellitus |
| spellingShingle | Chen Yang Huiyan Zhang Zihan Ma Yanjun Fan Yanan Xu Jian Tan Jing Tian Jiancang Cao Wenwen Zhang Gang Huang Lianping Zhao Structural and functional alterations of the hippocampal subfields in T2DM with mild cognitive impairment and insulin resistance: A prospective study Journal of Diabetes hippocampus insulin resistance magnetic resonance imaging mild cognitive impairment type 2 diabetes mellitus |
| title | Structural and functional alterations of the hippocampal subfields in T2DM with mild cognitive impairment and insulin resistance: A prospective study |
| title_full | Structural and functional alterations of the hippocampal subfields in T2DM with mild cognitive impairment and insulin resistance: A prospective study |
| title_fullStr | Structural and functional alterations of the hippocampal subfields in T2DM with mild cognitive impairment and insulin resistance: A prospective study |
| title_full_unstemmed | Structural and functional alterations of the hippocampal subfields in T2DM with mild cognitive impairment and insulin resistance: A prospective study |
| title_short | Structural and functional alterations of the hippocampal subfields in T2DM with mild cognitive impairment and insulin resistance: A prospective study |
| title_sort | structural and functional alterations of the hippocampal subfields in t2dm with mild cognitive impairment and insulin resistance a prospective study |
| topic | hippocampus insulin resistance magnetic resonance imaging mild cognitive impairment type 2 diabetes mellitus |
| url | https://doi.org/10.1111/1753-0407.70029 |
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