Contents of plasmin, α1-antitrypsin and α2-macroglobulin in blood of patients with cerebral infarction and discircular encephalopathy before the treatment
The aim of this investigation was to define the concentrations of serum proteinase — plasmin — and some of proteinase inhibitors, such as α2-macroglobulin (MG) and α1-antitrypsin (AT), in order to study their role in cerebral infarction (CI) and discircular encephalopathy (DE) pathogenesis. We have...
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Siberian State Medical University (Tomsk)
2004-09-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3681 |
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| author | N. A. Kuznetsova T. S. Chirikova N. A. Krayushkina V. N. Zorina |
| author_facet | N. A. Kuznetsova T. S. Chirikova N. A. Krayushkina V. N. Zorina |
| author_sort | N. A. Kuznetsova |
| collection | DOAJ |
| description | The aim of this investigation was to define the concentrations of serum proteinase — plasmin — and some of proteinase inhibitors, such as α2-macroglobulin (MG) and α1-antitrypsin (AT), in order to study their role in cerebral infarction (CI) and discircular encephalopathy (DE) pathogenesis. We have investigated 30 patients with cerebral infarction, 30 patients with discircular encephalopathy and 60 serum samples of the healthy people as a control. Plasmin (Pl), AT and MG levels have been defined with rocket immunoelectrophoresis method. We have found a significant Pl decrease in both group patients as compared to the control. The decrease has been (95,83 ± 4,3) mkg/ml in CI patients’ serum, (83,49 ± 3,79) mkg/ml in DE patients and (112,98 ± 2,66) mkg/ml in the control group. AT concentration has been increased in DE patients’ serum [(2,44 ± 0,15) g/l], MG concentration has decreased significantly [(1,08 ± 0/09) g/l] as compared to the control. On the contrary, MG serum concentration (1,72 ± 0/08 g/l) in CI patient group has not differed from the control [(1,64 ± 0,04) g/l] but it has been accompanied by AT level increase [(2,50 ± 0,16) g/l at patients and (1,78 ± 0,04) g/l at control]. We think that these differences can be used during differential diagnostics of the investigated diseases. |
| format | Article |
| id | doaj-art-35ea9e8fb45a46eba239e45c28e54774 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2004-09-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-35ea9e8fb45a46eba239e45c28e547742025-08-20T04:00:18ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842004-09-0133868910.20538/1682-0363-2004-3-86-892320Contents of plasmin, α1-antitrypsin and α2-macroglobulin in blood of patients with cerebral infarction and discircular encephalopathy before the treatmentN. A. Kuznetsova0T. S. Chirikova1N. A. Krayushkina2V. N. Zorina3Новокузнецкий институт усовершенствования врачей Минздрава РФ, Центральная научно-исследовательская лабораторияНовокузнецкий институт усовершенствования врачей Минздрава РФ, Центральная научно-исследовательская лабораторияНовокузнецкий институт усовершенствования врачей Минздрава РФ, Центральная научно-исследовательская лабораторияНовокузнецкий институт усовершенствования врачей Минздрава РФ, Центральная научно-исследовательская лабораторияThe aim of this investigation was to define the concentrations of serum proteinase — plasmin — and some of proteinase inhibitors, such as α2-macroglobulin (MG) and α1-antitrypsin (AT), in order to study their role in cerebral infarction (CI) and discircular encephalopathy (DE) pathogenesis. We have investigated 30 patients with cerebral infarction, 30 patients with discircular encephalopathy and 60 serum samples of the healthy people as a control. Plasmin (Pl), AT and MG levels have been defined with rocket immunoelectrophoresis method. We have found a significant Pl decrease in both group patients as compared to the control. The decrease has been (95,83 ± 4,3) mkg/ml in CI patients’ serum, (83,49 ± 3,79) mkg/ml in DE patients and (112,98 ± 2,66) mkg/ml in the control group. AT concentration has been increased in DE patients’ serum [(2,44 ± 0,15) g/l], MG concentration has decreased significantly [(1,08 ± 0/09) g/l] as compared to the control. On the contrary, MG serum concentration (1,72 ± 0/08 g/l) in CI patient group has not differed from the control [(1,64 ± 0,04) g/l] but it has been accompanied by AT level increase [(2,50 ± 0,16) g/l at patients and (1,78 ± 0,04) g/l at control]. We think that these differences can be used during differential diagnostics of the investigated diseases.https://bulletin.ssmu.ru/jour/article/view/3681cerebral infarctiondiscircular encephalopathyplasminα1-antitrypsinα2-macroglobulin |
| spellingShingle | N. A. Kuznetsova T. S. Chirikova N. A. Krayushkina V. N. Zorina Contents of plasmin, α1-antitrypsin and α2-macroglobulin in blood of patients with cerebral infarction and discircular encephalopathy before the treatment Бюллетень сибирской медицины cerebral infarction discircular encephalopathy plasmin α1-antitrypsin α2-macroglobulin |
| title | Contents of plasmin, α1-antitrypsin and α2-macroglobulin in blood of patients with cerebral infarction and discircular encephalopathy before the treatment |
| title_full | Contents of plasmin, α1-antitrypsin and α2-macroglobulin in blood of patients with cerebral infarction and discircular encephalopathy before the treatment |
| title_fullStr | Contents of plasmin, α1-antitrypsin and α2-macroglobulin in blood of patients with cerebral infarction and discircular encephalopathy before the treatment |
| title_full_unstemmed | Contents of plasmin, α1-antitrypsin and α2-macroglobulin in blood of patients with cerebral infarction and discircular encephalopathy before the treatment |
| title_short | Contents of plasmin, α1-antitrypsin and α2-macroglobulin in blood of patients with cerebral infarction and discircular encephalopathy before the treatment |
| title_sort | contents of plasmin α1 antitrypsin and α2 macroglobulin in blood of patients with cerebral infarction and discircular encephalopathy before the treatment |
| topic | cerebral infarction discircular encephalopathy plasmin α1-antitrypsin α2-macroglobulin |
| url | https://bulletin.ssmu.ru/jour/article/view/3681 |
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