Association between retinal morphological characteristics and visual function in myopic traction maculopathy
Objective: To quantify retinal morphological characteristics in patients with myopic traction maculopathy (MTM), including myopic foveoschisis (MF), using optical coherence tomography angiography (OCTA) and investigate the correlation of MTM with visual function. Methods: This cross-sectional study...
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Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024004733 |
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| author | Mengai Wu Lifeng Chen Yuanyuan Fan Li Lin Haidong Li Zhijie Wang Guanshun Yu Xinyue Wu Bin Zheng Fan Lu |
| author_facet | Mengai Wu Lifeng Chen Yuanyuan Fan Li Lin Haidong Li Zhijie Wang Guanshun Yu Xinyue Wu Bin Zheng Fan Lu |
| author_sort | Mengai Wu |
| collection | DOAJ |
| description | Objective: To quantify retinal morphological characteristics in patients with myopic traction maculopathy (MTM), including myopic foveoschisis (MF), using optical coherence tomography angiography (OCTA) and investigate the correlation of MTM with visual function. Methods: This cross-sectional study included 19 eyes with myopic foveoschisis (MF) and foveal detachment (FD), 37 eyes with MF without FD, and 24 myopic eyes as control. OCTA was used to assess macular vessel density (VD) in the superficial capillary plexus (SCP), deep capillary plexus (DCP), foveal avascular zone (FAZ) area, FAZ perimeter, acircularity index, retinal thickness, and retinal volume. Microperimetry was performed to evaluate macular sensitivity (MS) covering the central 20°, 10°, 2° field centered at fovea. Correlations between macular microcirculation parameters, best-corrected visual acuity (BCVA), and MS were determined. Results: Compared to myopic controls, decreased macular parafoveal SCP VD, DCP VD, and the area VD in a 300 µm wide annulus surrounding the FAZ (FD-300), were found in the group of MF patients with FD, with (p = 0.007, 0.002, 0.005) respectively, and in the group of MF patients without FD, with (p = 0.01, 0.049, 0.009), respectively. In the MF without FD group, parafoveal SCP VD significantly correlated with BCVA, 2°MS, 10°MS, and 20°MS (p = 0.018, 0.002, 0.001, 0.029), FD-300 area density, retinal thickness, and retinal volume was significantly correlated with BCVA (p = 0.024, 0.015, 0.045). In the MF with FD group, DCP VD was significantly associated with 10° and 20° MS (p = 0.048, 0.014), as were retinal thickness and volume (all p < 0.05); however, FD-300 area density correlated significantly with BCVA (p = 0.014). Conclusions: Macular perfusion is closely associated with functional alterations in MTM. Macular VD could serve as a valuable biomarker for monitoring MTM progression and optimizing medical and surgical decisions. |
| format | Article |
| id | doaj-art-35e8c7414d344af2b7338f9f7acc8c88 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-35e8c7414d344af2b7338f9f7acc8c882025-02-01T04:11:42ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104437Association between retinal morphological characteristics and visual function in myopic traction maculopathyMengai Wu0Lifeng Chen1Yuanyuan Fan2Li Lin3Haidong Li4Zhijie Wang5Guanshun Yu6Xinyue Wu7Bin Zheng8Fan Lu9National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang 325027, PR ChinaNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang 325027, PR ChinaNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang 325027, PR ChinaNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang 325027, PR ChinaNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang 325027, PR ChinaNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang 325027, PR ChinaNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang 325027, PR ChinaNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang 325027, PR ChinaCorresponding authors.; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang 325027, PR ChinaCorresponding authors.; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang 325027, PR ChinaObjective: To quantify retinal morphological characteristics in patients with myopic traction maculopathy (MTM), including myopic foveoschisis (MF), using optical coherence tomography angiography (OCTA) and investigate the correlation of MTM with visual function. Methods: This cross-sectional study included 19 eyes with myopic foveoschisis (MF) and foveal detachment (FD), 37 eyes with MF without FD, and 24 myopic eyes as control. OCTA was used to assess macular vessel density (VD) in the superficial capillary plexus (SCP), deep capillary plexus (DCP), foveal avascular zone (FAZ) area, FAZ perimeter, acircularity index, retinal thickness, and retinal volume. Microperimetry was performed to evaluate macular sensitivity (MS) covering the central 20°, 10°, 2° field centered at fovea. Correlations between macular microcirculation parameters, best-corrected visual acuity (BCVA), and MS were determined. Results: Compared to myopic controls, decreased macular parafoveal SCP VD, DCP VD, and the area VD in a 300 µm wide annulus surrounding the FAZ (FD-300), were found in the group of MF patients with FD, with (p = 0.007, 0.002, 0.005) respectively, and in the group of MF patients without FD, with (p = 0.01, 0.049, 0.009), respectively. In the MF without FD group, parafoveal SCP VD significantly correlated with BCVA, 2°MS, 10°MS, and 20°MS (p = 0.018, 0.002, 0.001, 0.029), FD-300 area density, retinal thickness, and retinal volume was significantly correlated with BCVA (p = 0.024, 0.015, 0.045). In the MF with FD group, DCP VD was significantly associated with 10° and 20° MS (p = 0.048, 0.014), as were retinal thickness and volume (all p < 0.05); however, FD-300 area density correlated significantly with BCVA (p = 0.014). Conclusions: Macular perfusion is closely associated with functional alterations in MTM. Macular VD could serve as a valuable biomarker for monitoring MTM progression and optimizing medical and surgical decisions.http://www.sciencedirect.com/science/article/pii/S1572100024004733Foveal detachmentMyopic traction maculopathyMyopic foveoschisisVessel densityVisual functionOCTA |
| spellingShingle | Mengai Wu Lifeng Chen Yuanyuan Fan Li Lin Haidong Li Zhijie Wang Guanshun Yu Xinyue Wu Bin Zheng Fan Lu Association between retinal morphological characteristics and visual function in myopic traction maculopathy Photodiagnosis and Photodynamic Therapy Foveal detachment Myopic traction maculopathy Myopic foveoschisis Vessel density Visual function OCTA |
| title | Association between retinal morphological characteristics and visual function in myopic traction maculopathy |
| title_full | Association between retinal morphological characteristics and visual function in myopic traction maculopathy |
| title_fullStr | Association between retinal morphological characteristics and visual function in myopic traction maculopathy |
| title_full_unstemmed | Association between retinal morphological characteristics and visual function in myopic traction maculopathy |
| title_short | Association between retinal morphological characteristics and visual function in myopic traction maculopathy |
| title_sort | association between retinal morphological characteristics and visual function in myopic traction maculopathy |
| topic | Foveal detachment Myopic traction maculopathy Myopic foveoschisis Vessel density Visual function OCTA |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024004733 |
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