Silencing RNA for MMPs May Be Utilized for Cardioprotection

Silencing RNA for MMPs May Be Utilized for Cardioprotection

Ischemia/reperfusion (I/R) injury is accompanied by an increase of matrix metalloproteinase 2 (MMP-2) activity, which degrades heart contractile proteins. The aim of the study was to investigate the effect of MMP-2 small interfering RNA (MMP-2 siRNA) administration on I/R heart. Isolated rat hearts...

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Bibliographic Details
Main Authors: Marta Banaszkiewicz, Anna Krzywonos-Zawadzka, Agnieszka Olejnik, Agnieszka Noszczyk-Nowak, Iwona Bil-Lula
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Cardiovascular Therapeutics
Online Access:http://dx.doi.org/10.1155/2022/9729018
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