Epidemiological serosurvey of chikungunya fever post outbreak at Tanjung Sepat, Malaysia
Introduction: Chikungunya fever is a mosquito-borne viral disease that usually presents with prominent arthralgia. An outbreak of chikungunya fever was reported in Tanjung Sepat, Malaysia in 2019. The outbreak was limited in size with a low number of cases being reported. The present study sought t...
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The Journal of Infection in Developing Countries
2023-01-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/16613 |
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| author | Chee-Sieng Khor Boon-Teong Teoh Sing-Sin Sam Hooi-Yuen Khoo Noor-Syahida Azizan AsmaAnati CheMatSeri Kim-Ling Chin Zur-Raiha Hamim Noor-Adila Mohamed-Romai-Noor Che-Norainon Yaacob Juraina Abd-Jamil Hai-Yen Lee Yih-Harng Soh Sazaly AbuBakar |
| author_facet | Chee-Sieng Khor Boon-Teong Teoh Sing-Sin Sam Hooi-Yuen Khoo Noor-Syahida Azizan AsmaAnati CheMatSeri Kim-Ling Chin Zur-Raiha Hamim Noor-Adila Mohamed-Romai-Noor Che-Norainon Yaacob Juraina Abd-Jamil Hai-Yen Lee Yih-Harng Soh Sazaly AbuBakar |
| author_sort | Chee-Sieng Khor |
| collection | DOAJ |
| description |
Introduction: Chikungunya fever is a mosquito-borne viral disease that usually presents with prominent arthralgia. An outbreak of chikungunya fever was reported in Tanjung Sepat, Malaysia in 2019. The outbreak was limited in size with a low number of cases being reported. The present study sought to determine the possible variables that could have affected the transmission of the infection.
Methodology: A cross-sectional study involving 149 healthy adult volunteers from Tanjung Sepat was performed soon after the outbreak had subsided. All the participants donated blood samples and completed the questionnaires. Laboratory detection of anti-CHIKV IgM and IgG antibodies was performed using enzyme-linked immunoassays (ELISA). Risk factors associated with chikungunya seropositivity were determined using logistic regression.
Results: The majority (72.5%, n = 108) of the study participants tested positive for CHIKV antibodies. Only 8.3% (n = 9) of the participants out of all the seropositive volunteers had an asymptomatic infection. Participants who resided with a febrile (p < 0.05, Exp(B) = 2.2, confidence interval [CI] 1.3-3.6) or a CHIKV-diagnosed person (p < 0.05, Exp(B) = 2.1, CI 1.2-3.6) in the same household were found likely to be tested positive for CHIKV antibodies.
Conclusions: Findings from the study support that asymptomatic CHIKV infections and indoor transmission occurred during the outbreak. Hence, widespread community testing and indoor use of mosquito repellent are among the possible measures that can be implemented to reduce CHIKV transmission during an outbreak.
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| format | Article |
| id | doaj-art-35e10d4180d449b3979c0f8b2fe70c65 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-35e10d4180d449b3979c0f8b2fe70c652025-08-20T02:57:52ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802023-01-01170110.3855/jidc.16613Epidemiological serosurvey of chikungunya fever post outbreak at Tanjung Sepat, MalaysiaChee-Sieng Khor0Boon-Teong Teoh1Sing-Sin Sam2Hooi-Yuen Khoo3Noor-Syahida Azizan4AsmaAnati CheMatSeri5Kim-Ling Chin6Zur-Raiha Hamim7Noor-Adila Mohamed-Romai-Noor8Che-Norainon Yaacob9Juraina Abd-Jamil10Hai-Yen Lee11Yih-Harng Soh12Sazaly AbuBakar13Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia Introduction: Chikungunya fever is a mosquito-borne viral disease that usually presents with prominent arthralgia. An outbreak of chikungunya fever was reported in Tanjung Sepat, Malaysia in 2019. The outbreak was limited in size with a low number of cases being reported. The present study sought to determine the possible variables that could have affected the transmission of the infection. Methodology: A cross-sectional study involving 149 healthy adult volunteers from Tanjung Sepat was performed soon after the outbreak had subsided. All the participants donated blood samples and completed the questionnaires. Laboratory detection of anti-CHIKV IgM and IgG antibodies was performed using enzyme-linked immunoassays (ELISA). Risk factors associated with chikungunya seropositivity were determined using logistic regression. Results: The majority (72.5%, n = 108) of the study participants tested positive for CHIKV antibodies. Only 8.3% (n = 9) of the participants out of all the seropositive volunteers had an asymptomatic infection. Participants who resided with a febrile (p < 0.05, Exp(B) = 2.2, confidence interval [CI] 1.3-3.6) or a CHIKV-diagnosed person (p < 0.05, Exp(B) = 2.1, CI 1.2-3.6) in the same household were found likely to be tested positive for CHIKV antibodies. Conclusions: Findings from the study support that asymptomatic CHIKV infections and indoor transmission occurred during the outbreak. Hence, widespread community testing and indoor use of mosquito repellent are among the possible measures that can be implemented to reduce CHIKV transmission during an outbreak. https://jidc.org/index.php/journal/article/view/16613chikungunyainfectious diseasesvector-borneseroprevalenceasymptomaticMalaysia |
| spellingShingle | Chee-Sieng Khor Boon-Teong Teoh Sing-Sin Sam Hooi-Yuen Khoo Noor-Syahida Azizan AsmaAnati CheMatSeri Kim-Ling Chin Zur-Raiha Hamim Noor-Adila Mohamed-Romai-Noor Che-Norainon Yaacob Juraina Abd-Jamil Hai-Yen Lee Yih-Harng Soh Sazaly AbuBakar Epidemiological serosurvey of chikungunya fever post outbreak at Tanjung Sepat, Malaysia Journal of Infection in Developing Countries chikungunya infectious diseases vector-borne seroprevalence asymptomatic Malaysia |
| title | Epidemiological serosurvey of chikungunya fever post outbreak at Tanjung Sepat, Malaysia |
| title_full | Epidemiological serosurvey of chikungunya fever post outbreak at Tanjung Sepat, Malaysia |
| title_fullStr | Epidemiological serosurvey of chikungunya fever post outbreak at Tanjung Sepat, Malaysia |
| title_full_unstemmed | Epidemiological serosurvey of chikungunya fever post outbreak at Tanjung Sepat, Malaysia |
| title_short | Epidemiological serosurvey of chikungunya fever post outbreak at Tanjung Sepat, Malaysia |
| title_sort | epidemiological serosurvey of chikungunya fever post outbreak at tanjung sepat malaysia |
| topic | chikungunya infectious diseases vector-borne seroprevalence asymptomatic Malaysia |
| url | https://jidc.org/index.php/journal/article/view/16613 |
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