FedECA: federated external control arms for causal inference with time-to-event data in distributed settings

FedECA: federated external control arms for causal inference with time-to-event data in distributed settings

Abstract External control arms can inform early clinical development of experimental drugs and provide efficacy evidence for regulatory approval. However, accessing sufficient real-world or historical clinical trials data is challenging. Indeed, regulations protecting patients’ rights by strictly co...

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Main Authors: Jean Ogier du Terrail, Quentin Klopfenstein, Honghao Li, Imke Mayer, Nicolas Loiseau, Mohammad Hallal, Michael Debouver, Thibault Camalon, Thibault Fouqueray, Jorge Arellano Castro, Zahia Yanes, Laëtitia Dahan, Julien Taïeb, Pierre Laurent-Puig, Jean-Baptiste Bachet, Shulin Zhao, Remy Nicolle, Jérôme Cros, Daniel Gonzalez, Robert Carreras-Torres, Adelaida Garcia Velasco, Kawther Abdilleh, Sudheer Doss, Félix Balazard, Mathieu Andreux
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62525-z
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