Serum metabolomic characteristics of COVID-19 patients co-infection with echovirus
Currently, the Omicron variant of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to circulate globally. In our multiplex respiratory pathogen detection, we identified numerous instances of co-infection with Echovirus (ECHO) among Coronavirus Disease 2019 (COVID-19) patien...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Virulence |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2025.2497907 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850196335639134208 |
|---|---|
| author | Chunhua Wang Tingyu Yu Ying Xia Feng Tao Jiali Sun Jianzhong Zhao Xiaogang Mao Mengjun Tang Lijuan Yin Yang Yang Wenjie Tan Liang Shen Shuaijie Zhang |
| author_facet | Chunhua Wang Tingyu Yu Ying Xia Feng Tao Jiali Sun Jianzhong Zhao Xiaogang Mao Mengjun Tang Lijuan Yin Yang Yang Wenjie Tan Liang Shen Shuaijie Zhang |
| author_sort | Chunhua Wang |
| collection | DOAJ |
| description | Currently, the Omicron variant of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to circulate globally. In our multiplex respiratory pathogen detection, we identified numerous instances of co-infection with Echovirus (ECHO) among Coronavirus Disease 2019 (COVID-19) patients, which exacerbated the clinical symptoms of these patients. Such co-infections are likely to impact the subsequent medical treatment. To date, there are no reports on the pathogenic mechanisms related to COVID-19 co-infected with ECHO. Therefore, this study employed the TM Widely-Targeted metabolomics approach to analyze the serum metabolomes of COVID-19 patients with single SARS-CoV-2 infection (COVID-19), COVID-19 patients co-infected with ECHO (COVID-19 + ECHO), and healthy individuals (Control) recruited from routine physical examinations during the same period. Concurrent clinical laboratory tests were performed on the patients to reveal the differences in metabolomic characteristics between the COVID-19 patients and the COVID-19 + ECHO patients, as well as to explore potential metabolic pathways that may exacerbate disease progression. Our findings indicate that both clinical examination indicators and the pathways enriched by differential metabolites confirm that patients with dual infection exhibit higher inflammatory and immune responses compared to those with single COVID-19 infections. This difference is likely reflected through abnormalities in the glycerophospholipid metabolic pathway, with the metabolite Sn-Glycero-3-Phosphocholine playing a crucial role in this process. Finally, we established a diagnostic model based on logistic regression using five differential metabolites, which accurately differentiates between the dual infection population and the single COVID-19 infection population (AUC = 0.828). |
| format | Article |
| id | doaj-art-35d9b97c873d4bd3a8f96a9e18815a63 |
| institution | OA Journals |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-35d9b97c873d4bd3a8f96a9e18815a632025-08-20T02:13:28ZengTaylor & Francis GroupVirulence2150-55942150-56082025-12-0116110.1080/21505594.2025.2497907Serum metabolomic characteristics of COVID-19 patients co-infection with echovirusChunhua Wang0Tingyu Yu1Ying Xia2Feng Tao3Jiali Sun4Jianzhong Zhao5Xiaogang Mao6Mengjun Tang7Lijuan Yin8Yang Yang9Wenjie Tan10Liang Shen11Shuaijie Zhang12Department of Clinical Laboratory, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Xiangyang, Hubei Province, ChinaDepartment of Central Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, ChinaDepartment of Central Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, ChinaThe Key Laboratory for Precision Diagnosis and Treatment of Thrombotic Diseases in Xiangyang City, Zaoyang First People’s Hospital, Zaoyang, Hubei Province, ChinaDepartment of Central Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, ChinaDepartment of Clinical Laboratory, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Xiangyang, Hubei Province, ChinaDepartment of Central Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, ChinaDepartment of Central Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, ChinaState Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering Lab of Metabolic Control Fermentation Technology, China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, ChinaShenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, ChinaNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaDepartment of Central Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, ChinaDepartment of Central Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, ChinaCurrently, the Omicron variant of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to circulate globally. In our multiplex respiratory pathogen detection, we identified numerous instances of co-infection with Echovirus (ECHO) among Coronavirus Disease 2019 (COVID-19) patients, which exacerbated the clinical symptoms of these patients. Such co-infections are likely to impact the subsequent medical treatment. To date, there are no reports on the pathogenic mechanisms related to COVID-19 co-infected with ECHO. Therefore, this study employed the TM Widely-Targeted metabolomics approach to analyze the serum metabolomes of COVID-19 patients with single SARS-CoV-2 infection (COVID-19), COVID-19 patients co-infected with ECHO (COVID-19 + ECHO), and healthy individuals (Control) recruited from routine physical examinations during the same period. Concurrent clinical laboratory tests were performed on the patients to reveal the differences in metabolomic characteristics between the COVID-19 patients and the COVID-19 + ECHO patients, as well as to explore potential metabolic pathways that may exacerbate disease progression. Our findings indicate that both clinical examination indicators and the pathways enriched by differential metabolites confirm that patients with dual infection exhibit higher inflammatory and immune responses compared to those with single COVID-19 infections. This difference is likely reflected through abnormalities in the glycerophospholipid metabolic pathway, with the metabolite Sn-Glycero-3-Phosphocholine playing a crucial role in this process. Finally, we established a diagnostic model based on logistic regression using five differential metabolites, which accurately differentiates between the dual infection population and the single COVID-19 infection population (AUC = 0.828).https://www.tandfonline.com/doi/10.1080/21505594.2025.2497907SARS-CoV-2echovirusco-infectionserum metabolites |
| spellingShingle | Chunhua Wang Tingyu Yu Ying Xia Feng Tao Jiali Sun Jianzhong Zhao Xiaogang Mao Mengjun Tang Lijuan Yin Yang Yang Wenjie Tan Liang Shen Shuaijie Zhang Serum metabolomic characteristics of COVID-19 patients co-infection with echovirus Virulence SARS-CoV-2 echovirus co-infection serum metabolites |
| title | Serum metabolomic characteristics of COVID-19 patients co-infection with echovirus |
| title_full | Serum metabolomic characteristics of COVID-19 patients co-infection with echovirus |
| title_fullStr | Serum metabolomic characteristics of COVID-19 patients co-infection with echovirus |
| title_full_unstemmed | Serum metabolomic characteristics of COVID-19 patients co-infection with echovirus |
| title_short | Serum metabolomic characteristics of COVID-19 patients co-infection with echovirus |
| title_sort | serum metabolomic characteristics of covid 19 patients co infection with echovirus |
| topic | SARS-CoV-2 echovirus co-infection serum metabolites |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2025.2497907 |
| work_keys_str_mv | AT chunhuawang serummetabolomiccharacteristicsofcovid19patientscoinfectionwithechovirus AT tingyuyu serummetabolomiccharacteristicsofcovid19patientscoinfectionwithechovirus AT yingxia serummetabolomiccharacteristicsofcovid19patientscoinfectionwithechovirus AT fengtao serummetabolomiccharacteristicsofcovid19patientscoinfectionwithechovirus AT jialisun serummetabolomiccharacteristicsofcovid19patientscoinfectionwithechovirus AT jianzhongzhao serummetabolomiccharacteristicsofcovid19patientscoinfectionwithechovirus AT xiaogangmao serummetabolomiccharacteristicsofcovid19patientscoinfectionwithechovirus AT mengjuntang serummetabolomiccharacteristicsofcovid19patientscoinfectionwithechovirus AT lijuanyin serummetabolomiccharacteristicsofcovid19patientscoinfectionwithechovirus AT yangyang serummetabolomiccharacteristicsofcovid19patientscoinfectionwithechovirus AT wenjietan serummetabolomiccharacteristicsofcovid19patientscoinfectionwithechovirus AT liangshen serummetabolomiccharacteristicsofcovid19patientscoinfectionwithechovirus AT shuaijiezhang serummetabolomiccharacteristicsofcovid19patientscoinfectionwithechovirus |