Emerging roles of HECT‐type E3 ubiquitin ligases in autophagy regulation

Emerging roles of HECT‐type E3 ubiquitin ligases in autophagy regulation

Autophagy is a conserved self‐eating process that delivers cytoplasmic material to the lysosome to allow degradation of intracellular components, including soluble, unfolded and aggregated proteins, damaged organelles, and invading microorganisms. Autophagy provides a homeostatic control mechanism a...

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Bibliographic Details
Main Authors: Gerry Melino, Francesco Cecconi, Pier Giuseppe Pelicci, Tak Wah Mak, Francesca Bernassola
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:Molecular Oncology
Subjects:
autophagy
HECT E3 ubiquitin ligases
proteasomal degradation
ubiquitylation
Online Access:https://doi.org/10.1002/1878-0261.12567
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