Emerging roles of HECT‐type E3 ubiquitin ligases in autophagy regulation
Autophagy is a conserved self‐eating process that delivers cytoplasmic material to the lysosome to allow degradation of intracellular components, including soluble, unfolded and aggregated proteins, damaged organelles, and invading microorganisms. Autophagy provides a homeostatic control mechanism a...
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| Format: | Article |
| Language: | English |
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Wiley
2019-10-01
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| Series: | Molecular Oncology |
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| Online Access: | https://doi.org/10.1002/1878-0261.12567 |
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| author | Gerry Melino Francesco Cecconi Pier Giuseppe Pelicci Tak Wah Mak Francesca Bernassola |
| author_facet | Gerry Melino Francesco Cecconi Pier Giuseppe Pelicci Tak Wah Mak Francesca Bernassola |
| author_sort | Gerry Melino |
| collection | DOAJ |
| description | Autophagy is a conserved self‐eating process that delivers cytoplasmic material to the lysosome to allow degradation of intracellular components, including soluble, unfolded and aggregated proteins, damaged organelles, and invading microorganisms. Autophagy provides a homeostatic control mechanism and is essential for balancing sources of energy in response to nutrient stress. Autophagic dysfunction or dysregulation has been implicated in several human pathologies, including cancer and neurodegeneration, and its modulation has substantial potential as a therapeutic strategy. Given the relevant clinical and therapeutic implications of autophagy, there is emerging intense interest in the identification of the key factors regulating the components of the autophagic machinery. Various post‐translational modifications, including ubiquitylation, have been implicated in autophagy control. The list of the E3 ubiquitin protein ligases involved in the regulation of several steps of the autophagic process is continuously growing. In this review, we will focus on recent advances in the understanding of the role of the homologous to the E6AP carboxyl terminus‐type E3 ubiquitin ligases in autophagy control. |
| format | Article |
| id | doaj-art-35d760b05bec46a5bb5d472a4f6e1894 |
| institution | DOAJ |
| issn | 1574-7891 1878-0261 |
| language | English |
| publishDate | 2019-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Oncology |
| spelling | doaj-art-35d760b05bec46a5bb5d472a4f6e18942025-08-20T03:11:10ZengWileyMolecular Oncology1574-78911878-02612019-10-0113102033204810.1002/1878-0261.12567Emerging roles of HECT‐type E3 ubiquitin ligases in autophagy regulationGerry Melino0Francesco Cecconi1Pier Giuseppe Pelicci2Tak Wah Mak3Francesca Bernassola4Department of Experimental Medicine TOR University of Rome “Tor Vergata” ItalyCell Stress and Survival Unit Danish Cancer Society Research Center Copenhagen DenmarkDepartment of Experimental Oncology IEO, European Institute of Oncology IRCCS Milan ItalyThe Campbell Family Institute for Breast Cancer Research Ontario Cancer Institute Princess Margaret Hospital Toronto ON CanadaDepartment of Experimental Medicine TOR University of Rome “Tor Vergata” ItalyAutophagy is a conserved self‐eating process that delivers cytoplasmic material to the lysosome to allow degradation of intracellular components, including soluble, unfolded and aggregated proteins, damaged organelles, and invading microorganisms. Autophagy provides a homeostatic control mechanism and is essential for balancing sources of energy in response to nutrient stress. Autophagic dysfunction or dysregulation has been implicated in several human pathologies, including cancer and neurodegeneration, and its modulation has substantial potential as a therapeutic strategy. Given the relevant clinical and therapeutic implications of autophagy, there is emerging intense interest in the identification of the key factors regulating the components of the autophagic machinery. Various post‐translational modifications, including ubiquitylation, have been implicated in autophagy control. The list of the E3 ubiquitin protein ligases involved in the regulation of several steps of the autophagic process is continuously growing. In this review, we will focus on recent advances in the understanding of the role of the homologous to the E6AP carboxyl terminus‐type E3 ubiquitin ligases in autophagy control.https://doi.org/10.1002/1878-0261.12567autophagyHECT E3 ubiquitin ligasesproteasomal degradationubiquitylation |
| spellingShingle | Gerry Melino Francesco Cecconi Pier Giuseppe Pelicci Tak Wah Mak Francesca Bernassola Emerging roles of HECT‐type E3 ubiquitin ligases in autophagy regulation Molecular Oncology autophagy HECT E3 ubiquitin ligases proteasomal degradation ubiquitylation |
| title | Emerging roles of HECT‐type E3 ubiquitin ligases in autophagy regulation |
| title_full | Emerging roles of HECT‐type E3 ubiquitin ligases in autophagy regulation |
| title_fullStr | Emerging roles of HECT‐type E3 ubiquitin ligases in autophagy regulation |
| title_full_unstemmed | Emerging roles of HECT‐type E3 ubiquitin ligases in autophagy regulation |
| title_short | Emerging roles of HECT‐type E3 ubiquitin ligases in autophagy regulation |
| title_sort | emerging roles of hect type e3 ubiquitin ligases in autophagy regulation |
| topic | autophagy HECT E3 ubiquitin ligases proteasomal degradation ubiquitylation |
| url | https://doi.org/10.1002/1878-0261.12567 |
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