The level of serum C-peptide signals fibrosis in obese patients with NAFLD
Abstract Nonalcoholic fatty liver disease (NAFLD) is considered one of the most common causes of chronic liver disease worldwide. Various scoring systems have been developed using different biomarkers to aid in the identification of fibrosis associated with NAFLD. The role of C-peptide in the pathop...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-07-01
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| Series: | The Egyptian Journal of Internal Medicine |
| Online Access: | https://doi.org/10.1186/s43162-025-00497-8 |
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| author | May Mohsen Fawzi Ghada Rabea Abd El Aziz Reham Alaa El Din Mohamed Manal Mohamed Kamal Ahmed El Shenawy |
| author_facet | May Mohsen Fawzi Ghada Rabea Abd El Aziz Reham Alaa El Din Mohamed Manal Mohamed Kamal Ahmed El Shenawy |
| author_sort | May Mohsen Fawzi |
| collection | DOAJ |
| description | Abstract Nonalcoholic fatty liver disease (NAFLD) is considered one of the most common causes of chronic liver disease worldwide. Various scoring systems have been developed using different biomarkers to aid in the identification of fibrosis associated with NAFLD. The role of C-peptide in the pathophysiology of liver fibrosis has become an increasingly important topic of research. Objective To correlate C-peptide level with NAFLD assessed by NFS and ultrasonography. Methods This study involved 118 participants, who were categorized into four groups based on ultrasound findings and BMI: the obese non-NAFLD group, the obese NAFLD group, the non-obese non-NAFLD group, and the non-obese NAFLD group. Anthropometric data (height, weight, BMI, and waist circumference), CBC, fasting blood glucose, 2-h postprandial blood glucose, HbA1c, ALT, AST, serum albumin, lipid profile, C-peptide, NFS, and abdominal ultrasound were done for all participants. Results Serum C-peptide levels demonstrated a statistically significant difference between the studied groups. C-peptide showed a strong positive correlation with weight, TG, with a p-value of 0.0001. The NFS was positively correlated with C-peptide. Abdominal US proved to be more effective than NAFLD scores in detecting fibrosis, with sensitivity rates of 100% compared to 44.1%. Conclusion There is a notable link between serum C-peptide levels and NFS found. C-peptide was strongly positively correlated with weight and dyslipidemia. NAFLD fibrosis score was moderately positively correlated with C-peptide. Abdominal ultrasonography was superior to NAFLD scores in the detection of fibrosis. |
| format | Article |
| id | doaj-art-35d72b56ec2a459db5550f5b123493cd |
| institution | Kabale University |
| issn | 2090-9098 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Internal Medicine |
| spelling | doaj-art-35d72b56ec2a459db5550f5b123493cd2025-08-20T03:42:03ZengSpringerOpenThe Egyptian Journal of Internal Medicine2090-90982025-07-0137111210.1186/s43162-025-00497-8The level of serum C-peptide signals fibrosis in obese patients with NAFLDMay Mohsen Fawzi0Ghada Rabea Abd El Aziz1Reham Alaa El Din Mohamed2Manal Mohamed Kamal3Ahmed El Shenawy4Internal Medicine Department, Faculty of Medicine, Cairo UniversityInternal Medicine Department, Faculty of Medicine, Cairo UniversityInternal Medicine Department, Faculty of Medicine, Cairo UniversityClinical and Chemical Pathology Department, Faculty of Medicine, Cairo UniversityInternal Medicine Department, Faculty of Medicine, Cairo UniversityAbstract Nonalcoholic fatty liver disease (NAFLD) is considered one of the most common causes of chronic liver disease worldwide. Various scoring systems have been developed using different biomarkers to aid in the identification of fibrosis associated with NAFLD. The role of C-peptide in the pathophysiology of liver fibrosis has become an increasingly important topic of research. Objective To correlate C-peptide level with NAFLD assessed by NFS and ultrasonography. Methods This study involved 118 participants, who were categorized into four groups based on ultrasound findings and BMI: the obese non-NAFLD group, the obese NAFLD group, the non-obese non-NAFLD group, and the non-obese NAFLD group. Anthropometric data (height, weight, BMI, and waist circumference), CBC, fasting blood glucose, 2-h postprandial blood glucose, HbA1c, ALT, AST, serum albumin, lipid profile, C-peptide, NFS, and abdominal ultrasound were done for all participants. Results Serum C-peptide levels demonstrated a statistically significant difference between the studied groups. C-peptide showed a strong positive correlation with weight, TG, with a p-value of 0.0001. The NFS was positively correlated with C-peptide. Abdominal US proved to be more effective than NAFLD scores in detecting fibrosis, with sensitivity rates of 100% compared to 44.1%. Conclusion There is a notable link between serum C-peptide levels and NFS found. C-peptide was strongly positively correlated with weight and dyslipidemia. NAFLD fibrosis score was moderately positively correlated with C-peptide. Abdominal ultrasonography was superior to NAFLD scores in the detection of fibrosis.https://doi.org/10.1186/s43162-025-00497-8 |
| spellingShingle | May Mohsen Fawzi Ghada Rabea Abd El Aziz Reham Alaa El Din Mohamed Manal Mohamed Kamal Ahmed El Shenawy The level of serum C-peptide signals fibrosis in obese patients with NAFLD The Egyptian Journal of Internal Medicine |
| title | The level of serum C-peptide signals fibrosis in obese patients with NAFLD |
| title_full | The level of serum C-peptide signals fibrosis in obese patients with NAFLD |
| title_fullStr | The level of serum C-peptide signals fibrosis in obese patients with NAFLD |
| title_full_unstemmed | The level of serum C-peptide signals fibrosis in obese patients with NAFLD |
| title_short | The level of serum C-peptide signals fibrosis in obese patients with NAFLD |
| title_sort | level of serum c peptide signals fibrosis in obese patients with nafld |
| url | https://doi.org/10.1186/s43162-025-00497-8 |
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