Hemostatic conditions following autologous transfusion of fresh vs stored platelets in experimental endotoxemia: an open-label randomized controlled trial with healthy volunteers

Hemostatic conditions following autologous transfusion of fresh vs stored platelets in experimental endotoxemia: an open-label randomized controlled trial with healthy volunteers

Background: Platelet increment is reportedly lower for maximum stored platelet concentrates (PCs) and during pyrexia, and in vitro function differs between fresh and stored PCs. However, little is known about the function of fresh and stored platelets during inflammation. Objectives: The aim was to...

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Main Authors: Stefan F. van Wonderen, Floor L.F. van Baarle, Anita M. Tuip-de Boer, Chantal A. Polet, Robin van Bruggen, Christie Vermeulen, Thomas R.L. Klei, Chi M. Hau, Rienk Nieuwland, Cornelis van ’t Veer, Anna L. Peters, Sanne de Bruin, Alexander P.J. Vlaar, Bart J. Biemond, Marcella C.A. Müller
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
endotoxemia
hemostasis
platelet
platelet transfusion
thromboelastography
Online Access:http://www.sciencedirect.com/science/article/pii/S2475037924003078
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