Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles
The mesolimbic dopamine (DA) system has been implicated in pair bond formation. However, the involvements of DA release, real-time activities, and electrophysiological activities of D1/D2 medium spiny neurons (MSNs) in the nucleus accumbens (NAc) shell in pair bonding remain unclear. This work verif...
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eLife Sciences Publications Ltd
2025-06-01
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| Online Access: | https://elifesciences.org/articles/100292 |
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| author | Lizi Zhang Yishan Qu Larry J Young Wenjuan Hou Limin Liu Jing Liu Yuqian Wang Lu Li Xing Guo Yin Li Caihong Huang Zijian Lv Yi-Tong Li Rui Jia Ting Lian Hao Feng Hui Qiao Zhixiong He Fa-Dao Tai |
| author_facet | Lizi Zhang Yishan Qu Larry J Young Wenjuan Hou Limin Liu Jing Liu Yuqian Wang Lu Li Xing Guo Yin Li Caihong Huang Zijian Lv Yi-Tong Li Rui Jia Ting Lian Hao Feng Hui Qiao Zhixiong He Fa-Dao Tai |
| author_sort | Lizi Zhang |
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| description | The mesolimbic dopamine (DA) system has been implicated in pair bond formation. However, the involvements of DA release, real-time activities, and electrophysiological activities of D1/D2 medium spiny neurons (MSNs) in the nucleus accumbens (NAc) shell in pair bonding remain unclear. This work verified that male mandarin voles after pair bonding released higher levels of DA in the NAc shell and displayed higher levels of D1 MSNs activity and lower levels of D2 MSNs activity upon sniffing their partners compared to upon sniffing an unknown female. Moreover, pair bonding induced differential alterations in both synaptic plasticity and neuronal intrinsic excitability in both D1 MSNs and D2 MSNs. In addition, chemogenetic inhibition of ventral pallidum (VP) -projecting D2 MSNs in the NAc shell enhanced pair bond formation, while chemogenetic activation of VP-projecting D2 MSNs in the NAc shell inhibited pair bond formation. These findings suggest that different neuronal activity of NAc shell D1 MSNs / D2 MSNs regulated by increasing DA release after pair bonding may be a neurobiological mechanism underlying pair bond formation. |
| format | Article |
| id | doaj-art-35d6d4b3058d4060a4e2c349083c3c77 |
| institution | OA Journals |
| issn | 2050-084X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | eLife Sciences Publications Ltd |
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| series | eLife |
| spelling | doaj-art-35d6d4b3058d4060a4e2c349083c3c772025-08-20T02:03:39ZengeLife Sciences Publications LtdeLife2050-084X2025-06-011310.7554/eLife.100292Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin volesLizi Zhang0Yishan Qu1https://orcid.org/0000-0002-1849-6361Larry J Young2https://orcid.org/0000-0003-2044-2239Wenjuan Hou3Limin Liu4Jing Liu5https://orcid.org/0000-0002-1139-4127Yuqian Wang6Lu Li7Xing Guo8Yin Li9Caihong Huang10Zijian Lv11Yi-Tong Li12Rui Jia13Ting Lian14Hao Feng15Hui Qiao16https://orcid.org/0000-0002-2476-4342Zhixiong He17Fa-Dao Tai18https://orcid.org/0000-0002-6804-4179Institute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaDepartment of Psychiatry and Behavioral Sciences, Silvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Emory National Primate Research Center, Emory University, Atlanta, United States; Center for Social Neural Networks, University of Tsukuba, Tsukuba, JapanInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaResearch Center for Prevention and Treatment of Respiratory Disease, School of Clinical Medicine, Xi'an Medical University, Xi'an, ChinaInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaInstitute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaThe mesolimbic dopamine (DA) system has been implicated in pair bond formation. However, the involvements of DA release, real-time activities, and electrophysiological activities of D1/D2 medium spiny neurons (MSNs) in the nucleus accumbens (NAc) shell in pair bonding remain unclear. This work verified that male mandarin voles after pair bonding released higher levels of DA in the NAc shell and displayed higher levels of D1 MSNs activity and lower levels of D2 MSNs activity upon sniffing their partners compared to upon sniffing an unknown female. Moreover, pair bonding induced differential alterations in both synaptic plasticity and neuronal intrinsic excitability in both D1 MSNs and D2 MSNs. In addition, chemogenetic inhibition of ventral pallidum (VP) -projecting D2 MSNs in the NAc shell enhanced pair bond formation, while chemogenetic activation of VP-projecting D2 MSNs in the NAc shell inhibited pair bond formation. These findings suggest that different neuronal activity of NAc shell D1 MSNs / D2 MSNs regulated by increasing DA release after pair bonding may be a neurobiological mechanism underlying pair bond formation.https://elifesciences.org/articles/100292dopaminenucleus accumbenspair bond;D1/D2 medium spiny neuronssynaptic transmission |
| spellingShingle | Lizi Zhang Yishan Qu Larry J Young Wenjuan Hou Limin Liu Jing Liu Yuqian Wang Lu Li Xing Guo Yin Li Caihong Huang Zijian Lv Yi-Tong Li Rui Jia Ting Lian Hao Feng Hui Qiao Zhixiong He Fa-Dao Tai Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles eLife dopamine nucleus accumbens pair bond; D1/D2 medium spiny neurons synaptic transmission |
| title | Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles |
| title_full | Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles |
| title_fullStr | Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles |
| title_full_unstemmed | Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles |
| title_short | Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles |
| title_sort | different roles of d1 d2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles |
| topic | dopamine nucleus accumbens pair bond; D1/D2 medium spiny neurons synaptic transmission |
| url | https://elifesciences.org/articles/100292 |
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