Systemic Chemotherapy for Progression of Brain Metastases in Extensive-Stage Small Cell Lung Cancer
Lung cancer is the most common cause of cancer related mortality in men and women. Approximately 15% of lung cancers are small cell type. Chemotherapy and radiation are the mainstay treatments. Currently, the standard chemotherapy regimen includes platinum/etoposide. For extensive small cell lung ca...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/620582 |
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| _version_ | 1849306224689938432 |
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| author | Nagla Abdel Karim Ananta Bhatt Lauren Chiec Richard Curry |
| author_facet | Nagla Abdel Karim Ananta Bhatt Lauren Chiec Richard Curry |
| author_sort | Nagla Abdel Karim |
| collection | DOAJ |
| description | Lung cancer is the most common cause of cancer related mortality in men and women. Approximately 15% of lung cancers are small cell type. Chemotherapy and radiation are the mainstay treatments. Currently, the standard chemotherapy regimen includes platinum/etoposide. For extensive small cell lung cancer, irinotecan and cisplatin have also been used. Patients with relapsed small cell lung cancer have a very poor prognosis, and the morbidity increases with brain metastases. Approximately 10%–14% of small cell lung cancer patients exhibit brain metastases at the time of diagnosis, which increases to 50%–80% as the disease progresses. Mean survival with brain metastases is reported to be less than six months, thus calling for improved regimens. Here we present a case series of patients treated with irinotecan for progressive brain metastases in small cell lung cancer, which serves as a reminder of the role of systemic chemotherapy in this setting. |
| format | Article |
| id | doaj-art-35d677e986124abcb1a29c29ab33efcf |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-35d677e986124abcb1a29c29ab33efcf2025-08-20T03:55:08ZengWileyCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/620582620582Systemic Chemotherapy for Progression of Brain Metastases in Extensive-Stage Small Cell Lung CancerNagla Abdel Karim0Ananta Bhatt1Lauren Chiec2Richard Curry3The Vontz Center for Molecular Studies, Cincinnati, OH 45267, USADepartment of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45219, USAUniversity of Cincinnati Medical Center, Cincinnati, OH 45219, USADepartment of Neurology and Rehabilitation Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45219, USALung cancer is the most common cause of cancer related mortality in men and women. Approximately 15% of lung cancers are small cell type. Chemotherapy and radiation are the mainstay treatments. Currently, the standard chemotherapy regimen includes platinum/etoposide. For extensive small cell lung cancer, irinotecan and cisplatin have also been used. Patients with relapsed small cell lung cancer have a very poor prognosis, and the morbidity increases with brain metastases. Approximately 10%–14% of small cell lung cancer patients exhibit brain metastases at the time of diagnosis, which increases to 50%–80% as the disease progresses. Mean survival with brain metastases is reported to be less than six months, thus calling for improved regimens. Here we present a case series of patients treated with irinotecan for progressive brain metastases in small cell lung cancer, which serves as a reminder of the role of systemic chemotherapy in this setting.http://dx.doi.org/10.1155/2015/620582 |
| spellingShingle | Nagla Abdel Karim Ananta Bhatt Lauren Chiec Richard Curry Systemic Chemotherapy for Progression of Brain Metastases in Extensive-Stage Small Cell Lung Cancer Case Reports in Oncological Medicine |
| title | Systemic Chemotherapy for Progression of Brain Metastases in Extensive-Stage Small Cell Lung Cancer |
| title_full | Systemic Chemotherapy for Progression of Brain Metastases in Extensive-Stage Small Cell Lung Cancer |
| title_fullStr | Systemic Chemotherapy for Progression of Brain Metastases in Extensive-Stage Small Cell Lung Cancer |
| title_full_unstemmed | Systemic Chemotherapy for Progression of Brain Metastases in Extensive-Stage Small Cell Lung Cancer |
| title_short | Systemic Chemotherapy for Progression of Brain Metastases in Extensive-Stage Small Cell Lung Cancer |
| title_sort | systemic chemotherapy for progression of brain metastases in extensive stage small cell lung cancer |
| url | http://dx.doi.org/10.1155/2015/620582 |
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