Lost Rate Control and Tachycardia-Induced Cardiomyopathy as a Result of an Interaction Between Enzalutamide and Diltiazem

Lost Rate Control and Tachycardia-Induced Cardiomyopathy as a Result of an Interaction Between Enzalutamide and Diltiazem

Background: There is a theoretical drug interaction between enzalutamide, a potent cytochrome P 3A4 (CYP 3A4) inducer, and diltiazem, a CYP3A4 substrate. Resources recommend avoiding the combination. Case Summary: The patient was taking diltiazem for rate control of permanent atrial fibrillation. Af...

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Bibliographic Details
Main Authors: Adrian de Boer, PharmD, Sheri Koshman, BSPharm, PharmD, Gabor Gyenes, MD, PhD
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:JACC: Case Reports
Subjects:
acute heart failure
atrial fibrillation
cancer
cardiomyopathy
complication
ejection fraction
Online Access:http://www.sciencedirect.com/science/article/pii/S266608492500659X
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