Risk factors for poor outcome of patients with Coronavirus disease 2019 (COVID-19) in Albania
Introduction: The study aims to identify potential risk factors for the poor outcome of hospitalized patients with SARS-CoV-2 infection in Albania. Methodology: A retrospective observational study on 133 consecutive hospitalized patients at “COVID 1” Hospital, University Hospital Center of Tiran...
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The Journal of Infection in Developing Countries
2021-09-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/14592 |
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| author | Ergys Ramosaço Entela Kolovani Najada Çomo Nevila Gjermeni Vjollca Shpata Dhimiter Kraja |
| author_facet | Ergys Ramosaço Entela Kolovani Najada Çomo Nevila Gjermeni Vjollca Shpata Dhimiter Kraja |
| author_sort | Ergys Ramosaço |
| collection | DOAJ |
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Introduction: The study aims to identify potential risk factors for the poor outcome of hospitalized patients with SARS-CoV-2 infection in Albania.
Methodology: A retrospective observational study on 133 consecutive hospitalized patients at “COVID 1” Hospital, University Hospital Center of Tirana. The study analyzed the correlation between potential risk factors and in-hospital mortality.
Results: The study included 133 patients, 65.4% of the patients were male, age 60.46 ± 13.53 years. The mortality rate resulted in 22.6%. Univariate analysis revealed that early risk factors for mortality included: laboratory alterations on admission, such as lymphocytes count < 1.000/mm3 (OR = 3.30, 95% CI = 1.17-9.33), lactate dehydrogenase > 250 U/L (OR = 12.48, 95% CI = 1.62-95.78) and D dimer > 2 mg/L (OR = 4.72, 95% CI = 1.96-11.36); lung parenchymal involvement > 75% on chest computed tomography on admission (OR = 54.00, 95% CI = 11.89 – 245.11). Cox proportional hazard regression showed that independent risk factors for mortality were lung parenchymal involvement > 75% on chest computed tomography (HR = 8.31, 95%CI: 1.62-42.45) and occurrence of complications during hospital stay (OR = 10.28, 95% CI = 2.02-52.33).
Conclusions: The risk of poor outcome can be predicted from the early stage of COVID 19 disease, using laboratory data and chest computed tomography. Among patients with COVID 19, lung parenchymal involvement and alterations > 75% on chest computed tomography on admission and laboratory findings, such as lymphocytopenia, and elevated lactate dehydrogenase and D dimer levels, turned out to be early risk factors for in-hospital mortality.
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| format | Article |
| id | doaj-art-35d5247a5c32492997f3bb4d94ef87ce |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-35d5247a5c32492997f3bb4d94ef87ce2025-08-20T03:52:39ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802021-09-01150910.3855/jidc.14592Risk factors for poor outcome of patients with Coronavirus disease 2019 (COVID-19) in AlbaniaErgys Ramosaço0Entela Kolovani1Najada Çomo2Nevila Gjermeni3Vjollca Shpata4Dhimiter Kraja5Infectious Disease Clinic, University Hospital Center “Mother Theresa”, Tirana, AlbaniaInfectious Disease Clinic, University Hospital Center “Mother Theresa”, Tirana, AlbaniaInfectious Disease Clinic, University Hospital Center “Mother Theresa”, Tirana, AlbaniaInfectious Disease Clinic, University Hospital Center “Mother Theresa”, Tirana, AlbaniaDepartment of Clinical Sciences, Faculty of Medical Technical Sciences, University of Medicine in Tirana, AlbaniaInfectious Disease Clinic, University Hospital Center “Mother Theresa”, Tirana, Albania Introduction: The study aims to identify potential risk factors for the poor outcome of hospitalized patients with SARS-CoV-2 infection in Albania. Methodology: A retrospective observational study on 133 consecutive hospitalized patients at “COVID 1” Hospital, University Hospital Center of Tirana. The study analyzed the correlation between potential risk factors and in-hospital mortality. Results: The study included 133 patients, 65.4% of the patients were male, age 60.46 ± 13.53 years. The mortality rate resulted in 22.6%. Univariate analysis revealed that early risk factors for mortality included: laboratory alterations on admission, such as lymphocytes count < 1.000/mm3 (OR = 3.30, 95% CI = 1.17-9.33), lactate dehydrogenase > 250 U/L (OR = 12.48, 95% CI = 1.62-95.78) and D dimer > 2 mg/L (OR = 4.72, 95% CI = 1.96-11.36); lung parenchymal involvement > 75% on chest computed tomography on admission (OR = 54.00, 95% CI = 11.89 – 245.11). Cox proportional hazard regression showed that independent risk factors for mortality were lung parenchymal involvement > 75% on chest computed tomography (HR = 8.31, 95%CI: 1.62-42.45) and occurrence of complications during hospital stay (OR = 10.28, 95% CI = 2.02-52.33). Conclusions: The risk of poor outcome can be predicted from the early stage of COVID 19 disease, using laboratory data and chest computed tomography. Among patients with COVID 19, lung parenchymal involvement and alterations > 75% on chest computed tomography on admission and laboratory findings, such as lymphocytopenia, and elevated lactate dehydrogenase and D dimer levels, turned out to be early risk factors for in-hospital mortality. https://jidc.org/index.php/journal/article/view/14592coronavirus disease 2019COVID-19outcomemortalityrisk factorscomplication |
| spellingShingle | Ergys Ramosaço Entela Kolovani Najada Çomo Nevila Gjermeni Vjollca Shpata Dhimiter Kraja Risk factors for poor outcome of patients with Coronavirus disease 2019 (COVID-19) in Albania Journal of Infection in Developing Countries coronavirus disease 2019 COVID-19 outcome mortality risk factors complication |
| title | Risk factors for poor outcome of patients with Coronavirus disease 2019 (COVID-19) in Albania |
| title_full | Risk factors for poor outcome of patients with Coronavirus disease 2019 (COVID-19) in Albania |
| title_fullStr | Risk factors for poor outcome of patients with Coronavirus disease 2019 (COVID-19) in Albania |
| title_full_unstemmed | Risk factors for poor outcome of patients with Coronavirus disease 2019 (COVID-19) in Albania |
| title_short | Risk factors for poor outcome of patients with Coronavirus disease 2019 (COVID-19) in Albania |
| title_sort | risk factors for poor outcome of patients with coronavirus disease 2019 covid 19 in albania |
| topic | coronavirus disease 2019 COVID-19 outcome mortality risk factors complication |
| url | https://jidc.org/index.php/journal/article/view/14592 |
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