Unraveling breast cancer response to neoadjuvant chemotherapy through integrated genomic, transcriptomic, and circulating tumor DNA analysis

Unraveling breast cancer response to neoadjuvant chemotherapy through integrated genomic, transcriptomic, and circulating tumor DNA analysis

Abstract Introduction Neoadjuvant chemotherapy (NAC) is a standard treatment for breast cancer (BC) to shrink tumors and facilitate surgery. However, the molecular underpinnings of response to NAC and prognosis have not been well characterized. Methods We enrolled 73 stage II/III BC patients who rec...

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Main Authors: Menghao Dong, Jian Chen, Nannan Lu, Song Wang, Wenhui Wei, Ziming Wang, Jinnan Wang, Jinguo Zhang, Xinghua Han, Fufeng Wang, Qiuxiang Ou, Hua Bao, Xiaopeng Ma, Benjie Shan, Yueyin Pan
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Breast Cancer Research
Subjects:
Pathological complete response
Neoadjuvant chemotherapy
Breast cancer
Molecular biomarkers
Online Access:https://doi.org/10.1186/s13058-025-02026-5
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