The prognostic effect of immunohistochemical staining rates in patients with non–muscle-invasive bladder cancer
Context: Despite the follow-up protocols developed in non–muscle-invasive bladder cancer patients, progression and recurrence could not be prevented. Aims: We aimed to investigate whether proteins such as OCT-4, CD47, p53, Ki-67, and Survivin, which increase in bladder cancer cells, can be used as p...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-07-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_1236_21 |
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| author | Aykut Demirci Melike Ordu |
| author_facet | Aykut Demirci Melike Ordu |
| author_sort | Aykut Demirci |
| collection | DOAJ |
| description | Context:
Despite the follow-up protocols developed in non–muscle-invasive bladder cancer patients, progression and recurrence could not be prevented.
Aims:
We aimed to investigate whether proteins such as OCT-4, CD47, p53, Ki-67, and Survivin, which increase in bladder cancer cells, can be used as prognostic markers for patients with non–muscle-invasive bladder cancer.
Settings and Design:
The study included a total of 89 patients with newly diagnosed non–muscle-invasive bladder cancer between January 2015 and December 2020.
Materials and Methods:
Levels of OCT-4, CD47, p53, Kİ-67, and Survivin proteins in cancer cells were determined with a semi-quantitative immunohistochemical experiment. Pathological data and survival rates were compared according to the staining rates.
Statistical Analysis Used:
Data obtained in the study were analyzed statistically with SPSS 22.0 (SPSS, Chicago, IL, USA).
Results:
The mean age of the patients was 64.25 ± 9.91 years, and the median follow-up period was 55 months. Recurrence rate was determined to be 36% (n = 32), and the rate of progression at 40.4% (n = 36). The staining rates were stronger for each marker in the progression group and advanced-stage tumors (p < 0.001). The findings of the multivariate analysis carried out as part of the study showed that older age and higher tumor stage were independent risk factors for recurrence-free survival (HR = 1.048 and 7.074, respectively; P = 0.02). Also, higher tumor stages, diameters, and grades were associated with reduced progression-free survival (HR = 0.105, 0.395, 0.225, respectively; P < 0.05).
Conclusions:
Although immunohistochemical staining rates are promising, it is more appropriate to use tumor characteristics when assessing survival rate in patients with non–muscle-invasive bladder cancer. |
| format | Article |
| id | doaj-art-35ce8d169c644239bf2ddff40f82eb82 |
| institution | Kabale University |
| issn | 0377-4929 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-35ce8d169c644239bf2ddff40f82eb822025-02-07T13:30:46ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292023-07-0166350251010.4103/ijpm.ijpm_1236_21The prognostic effect of immunohistochemical staining rates in patients with non–muscle-invasive bladder cancerAykut DemirciMelike OrduContext: Despite the follow-up protocols developed in non–muscle-invasive bladder cancer patients, progression and recurrence could not be prevented. Aims: We aimed to investigate whether proteins such as OCT-4, CD47, p53, Ki-67, and Survivin, which increase in bladder cancer cells, can be used as prognostic markers for patients with non–muscle-invasive bladder cancer. Settings and Design: The study included a total of 89 patients with newly diagnosed non–muscle-invasive bladder cancer between January 2015 and December 2020. Materials and Methods: Levels of OCT-4, CD47, p53, Kİ-67, and Survivin proteins in cancer cells were determined with a semi-quantitative immunohistochemical experiment. Pathological data and survival rates were compared according to the staining rates. Statistical Analysis Used: Data obtained in the study were analyzed statistically with SPSS 22.0 (SPSS, Chicago, IL, USA). Results: The mean age of the patients was 64.25 ± 9.91 years, and the median follow-up period was 55 months. Recurrence rate was determined to be 36% (n = 32), and the rate of progression at 40.4% (n = 36). The staining rates were stronger for each marker in the progression group and advanced-stage tumors (p < 0.001). The findings of the multivariate analysis carried out as part of the study showed that older age and higher tumor stage were independent risk factors for recurrence-free survival (HR = 1.048 and 7.074, respectively; P = 0.02). Also, higher tumor stages, diameters, and grades were associated with reduced progression-free survival (HR = 0.105, 0.395, 0.225, respectively; P < 0.05). Conclusions: Although immunohistochemical staining rates are promising, it is more appropriate to use tumor characteristics when assessing survival rate in patients with non–muscle-invasive bladder cancer.https://journals.lww.com/10.4103/ijpm.ijpm_1236_21bladder cancercd47ki̇-67oct-4p53survivin |
| spellingShingle | Aykut Demirci Melike Ordu The prognostic effect of immunohistochemical staining rates in patients with non–muscle-invasive bladder cancer Indian Journal of Pathology and Microbiology bladder cancer cd47 ki̇-67 oct-4 p53 survivin |
| title | The prognostic effect of immunohistochemical staining rates in patients with non–muscle-invasive bladder cancer |
| title_full | The prognostic effect of immunohistochemical staining rates in patients with non–muscle-invasive bladder cancer |
| title_fullStr | The prognostic effect of immunohistochemical staining rates in patients with non–muscle-invasive bladder cancer |
| title_full_unstemmed | The prognostic effect of immunohistochemical staining rates in patients with non–muscle-invasive bladder cancer |
| title_short | The prognostic effect of immunohistochemical staining rates in patients with non–muscle-invasive bladder cancer |
| title_sort | prognostic effect of immunohistochemical staining rates in patients with non muscle invasive bladder cancer |
| topic | bladder cancer cd47 ki̇-67 oct-4 p53 survivin |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_1236_21 |
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