Harnessing the Power of Machine Learning Guided Discovery of NLRP3 Inhibitors Towards the Effective Treatment of Rheumatoid Arthritis

Harnessing the Power of Machine Learning Guided Discovery of NLRP3 Inhibitors Towards the Effective Treatment of Rheumatoid Arthritis

The NLRP3 inflammasome, plays a critical role in the pathogenesis of rheumatoid arthritis (RA) by activating inflammatory cytokines such as IL1β and IL18. Targeting NLRP3 has emerged as a promising therapeutic strategy for RA. In this study, a multidisciplinary approach combining machine learning, q...

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Bibliographic Details
Main Authors: Sidra Ilyas, Abdul Manan, Chanyoon Park, Hee-Geun Jo, Donghun Lee
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
NLRP3
machine learning
QSAR
docking
MD simulation
rheumatoid arthritis
Online Access:https://www.mdpi.com/2073-4409/14/1/27
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