Exploring the combined diagnostic role of serum MBL in association with renal resistive index and renal shear wave elastography in diabetic kidney disease patients
Abstract Background One of the most prevalent non-communicable diseases in the world today is diabetes. Diabetic kidney disease (DKD) is the predominant etiology of chronic kidney disease (CKD) and a major side effect of diabetes. Diagnosis of DKD is challenging and imprecise; thus, new diagnostic m...
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2025-05-01
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| Series: | Beni-Suef University Journal of Basic and Applied Sciences |
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| Online Access: | https://doi.org/10.1186/s43088-025-00645-7 |
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| author | Enas Ahmed Osman Khaled Mabrouk Ahmed Abdelsamie Mahmoud Medhat Madbouly Mohamed Moharam Mohamed Hussin Osama Mosbah Nevine Sherif Mohammed Ghanem Gaber Farida M. Khanany |
| author_facet | Enas Ahmed Osman Khaled Mabrouk Ahmed Abdelsamie Mahmoud Medhat Madbouly Mohamed Moharam Mohamed Hussin Osama Mosbah Nevine Sherif Mohammed Ghanem Gaber Farida M. Khanany |
| author_sort | Enas Ahmed Osman |
| collection | DOAJ |
| description | Abstract Background One of the most prevalent non-communicable diseases in the world today is diabetes. Diabetic kidney disease (DKD) is the predominant etiology of chronic kidney disease (CKD) and a major side effect of diabetes. Diagnosis of DKD is challenging and imprecise; thus, new diagnostic modalities are necessary to address this problem. The aim of the present study is to assess the role of the combined diagnostic performance of serum levels of MBL and imaging techniques, Doppler ultrasonographic renal resistive index (RRI) and shear wave elastography as a diagnostic tool for diabetic nephropathy. This case–control study included 450 type 2 diabetes mellitus (T2DM) patients, 225 without nephropathy and 225 diagnosed with diabetic nephropathy. We evaluated serum mannose-binding lectin (MBL) by enzyme-linked immunosorbent assay (ELISA) as a marker of diabetes-related inflammation, Doppler ultrasonographic renal resistive index (RRI) as a tool for assessment of blood flow in the kidney and shear wave elastography (SWE) as an imaging technique for detection of kidney fibrosis. Result The average serum MBL levels, mean RI and SWE of both kidneys were significantly higher in DKD patients compared to T2DM patients without nephropathy. The integration of the aforementioned methodologies significantly enhanced diagnostic performance, achieving a sensitivity of 96.89% and a specificity of 95.11%. Conclusion Combined serum levels of MBL and imaging techniques, Doppler ultrasonographic renal RI and shear wave elastography are promising diagnostic tools of diabetic nephropathy. |
| format | Article |
| id | doaj-art-35cbb5f358bb43009dc3e424522b6a44 |
| institution | OA Journals |
| issn | 2314-8543 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Beni-Suef University Journal of Basic and Applied Sciences |
| spelling | doaj-art-35cbb5f358bb43009dc3e424522b6a442025-08-20T01:59:57ZengSpringerOpenBeni-Suef University Journal of Basic and Applied Sciences2314-85432025-05-0114111110.1186/s43088-025-00645-7Exploring the combined diagnostic role of serum MBL in association with renal resistive index and renal shear wave elastography in diabetic kidney disease patientsEnas Ahmed Osman0Khaled Mabrouk1Ahmed Abdelsamie Mahmoud2Medhat Madbouly3Mohamed Moharam Mohamed Hussin4Osama Mosbah5Nevine Sherif6Mohammed Ghanem Gaber7Farida M. Khanany8Theodor Bilharz Research InstituteTheodor Bilharz Research InstituteTheodor Bilharz Research InstituteTheodor Bilharz Research InstituteTheodor Bilharz Research InstituteTheodor Bilharz Research InstituteTheodor Bilharz Research InstituteTheodor Bilharz Research InstituteTheodor Bilharz Research InstituteAbstract Background One of the most prevalent non-communicable diseases in the world today is diabetes. Diabetic kidney disease (DKD) is the predominant etiology of chronic kidney disease (CKD) and a major side effect of diabetes. Diagnosis of DKD is challenging and imprecise; thus, new diagnostic modalities are necessary to address this problem. The aim of the present study is to assess the role of the combined diagnostic performance of serum levels of MBL and imaging techniques, Doppler ultrasonographic renal resistive index (RRI) and shear wave elastography as a diagnostic tool for diabetic nephropathy. This case–control study included 450 type 2 diabetes mellitus (T2DM) patients, 225 without nephropathy and 225 diagnosed with diabetic nephropathy. We evaluated serum mannose-binding lectin (MBL) by enzyme-linked immunosorbent assay (ELISA) as a marker of diabetes-related inflammation, Doppler ultrasonographic renal resistive index (RRI) as a tool for assessment of blood flow in the kidney and shear wave elastography (SWE) as an imaging technique for detection of kidney fibrosis. Result The average serum MBL levels, mean RI and SWE of both kidneys were significantly higher in DKD patients compared to T2DM patients without nephropathy. The integration of the aforementioned methodologies significantly enhanced diagnostic performance, achieving a sensitivity of 96.89% and a specificity of 95.11%. Conclusion Combined serum levels of MBL and imaging techniques, Doppler ultrasonographic renal RI and shear wave elastography are promising diagnostic tools of diabetic nephropathy.https://doi.org/10.1186/s43088-025-00645-7Diabetic nephropathySerum mannose-binding lectinRenal resistive indexShear wave elastography |
| spellingShingle | Enas Ahmed Osman Khaled Mabrouk Ahmed Abdelsamie Mahmoud Medhat Madbouly Mohamed Moharam Mohamed Hussin Osama Mosbah Nevine Sherif Mohammed Ghanem Gaber Farida M. Khanany Exploring the combined diagnostic role of serum MBL in association with renal resistive index and renal shear wave elastography in diabetic kidney disease patients Beni-Suef University Journal of Basic and Applied Sciences Diabetic nephropathy Serum mannose-binding lectin Renal resistive index Shear wave elastography |
| title | Exploring the combined diagnostic role of serum MBL in association with renal resistive index and renal shear wave elastography in diabetic kidney disease patients |
| title_full | Exploring the combined diagnostic role of serum MBL in association with renal resistive index and renal shear wave elastography in diabetic kidney disease patients |
| title_fullStr | Exploring the combined diagnostic role of serum MBL in association with renal resistive index and renal shear wave elastography in diabetic kidney disease patients |
| title_full_unstemmed | Exploring the combined diagnostic role of serum MBL in association with renal resistive index and renal shear wave elastography in diabetic kidney disease patients |
| title_short | Exploring the combined diagnostic role of serum MBL in association with renal resistive index and renal shear wave elastography in diabetic kidney disease patients |
| title_sort | exploring the combined diagnostic role of serum mbl in association with renal resistive index and renal shear wave elastography in diabetic kidney disease patients |
| topic | Diabetic nephropathy Serum mannose-binding lectin Renal resistive index Shear wave elastography |
| url | https://doi.org/10.1186/s43088-025-00645-7 |
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