Helicobacter suis-Associated Gastritis Mimicking Conventional H. pylori-Associated Atrophic Gastritis

A 45-year-old Japanese man underwent esophagogastroduodenoscopy, which revealed spotty redness at the gastric fornix, mucosal swelling, diffuse redness in the corpus, and mucosal atrophy in the gastric angle and antrum. Histological examination showed rod-shaped bacteria that appeared larger than He...

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Main Authors: Masaya Iwamuro, Somay Yamagata Murayama, Masahiko Nakamura, Kenta Hamada, Takehiro Tanaka, Hiroyuki Okada
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Case Reports in Gastrointestinal Medicine
Online Access:http://dx.doi.org/10.1155/2022/4254605
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author Masaya Iwamuro
Somay Yamagata Murayama
Masahiko Nakamura
Kenta Hamada
Takehiro Tanaka
Hiroyuki Okada
author_facet Masaya Iwamuro
Somay Yamagata Murayama
Masahiko Nakamura
Kenta Hamada
Takehiro Tanaka
Hiroyuki Okada
author_sort Masaya Iwamuro
collection DOAJ
description A 45-year-old Japanese man underwent esophagogastroduodenoscopy, which revealed spotty redness at the gastric fornix, mucosal swelling, diffuse redness in the corpus, and mucosal atrophy in the gastric angle and antrum. Histological examination showed rod-shaped bacteria that appeared larger than Helicobacter pylori. The patient tested positive for rapid urease test, and serum anti-H. pylori IgG antibody test results were negative. Further examination of the bacteria revealed that H. suis antibody test was positive, and the presence of H. suis was confirmed using H. suis-specific real-time PCR. H. suis was successfully eradicated after triple therapy with vonoprazan, amoxicillin, and clarithromycin. This case reinforces the notion that non-H. pylori Helicobacter species such as H. suis and H. heilmannii may be involved in the pathogenesis of active gastritis in patients who test negative for H. pylori antibodies.
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issn 2090-6536
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series Case Reports in Gastrointestinal Medicine
spelling doaj-art-35ca1bc4fd5c464cb0b3efd83ec0f8412025-08-20T02:24:07ZengWileyCase Reports in Gastrointestinal Medicine2090-65362022-01-01202210.1155/2022/4254605Helicobacter suis-Associated Gastritis Mimicking Conventional H. pylori-Associated Atrophic GastritisMasaya Iwamuro0Somay Yamagata Murayama1Masahiko Nakamura2Kenta Hamada3Takehiro Tanaka4Hiroyuki Okada5Department of Gastroenterology and HepatologyDepartment of Fungal InfectionOmura Satoshi Memorial InstituteDepartment of Gastroenterology and HepatologyDepartment of PathologyDepartment of Gastroenterology and HepatologyA 45-year-old Japanese man underwent esophagogastroduodenoscopy, which revealed spotty redness at the gastric fornix, mucosal swelling, diffuse redness in the corpus, and mucosal atrophy in the gastric angle and antrum. Histological examination showed rod-shaped bacteria that appeared larger than Helicobacter pylori. The patient tested positive for rapid urease test, and serum anti-H. pylori IgG antibody test results were negative. Further examination of the bacteria revealed that H. suis antibody test was positive, and the presence of H. suis was confirmed using H. suis-specific real-time PCR. H. suis was successfully eradicated after triple therapy with vonoprazan, amoxicillin, and clarithromycin. This case reinforces the notion that non-H. pylori Helicobacter species such as H. suis and H. heilmannii may be involved in the pathogenesis of active gastritis in patients who test negative for H. pylori antibodies.http://dx.doi.org/10.1155/2022/4254605
spellingShingle Masaya Iwamuro
Somay Yamagata Murayama
Masahiko Nakamura
Kenta Hamada
Takehiro Tanaka
Hiroyuki Okada
Helicobacter suis-Associated Gastritis Mimicking Conventional H. pylori-Associated Atrophic Gastritis
Case Reports in Gastrointestinal Medicine
title Helicobacter suis-Associated Gastritis Mimicking Conventional H. pylori-Associated Atrophic Gastritis
title_full Helicobacter suis-Associated Gastritis Mimicking Conventional H. pylori-Associated Atrophic Gastritis
title_fullStr Helicobacter suis-Associated Gastritis Mimicking Conventional H. pylori-Associated Atrophic Gastritis
title_full_unstemmed Helicobacter suis-Associated Gastritis Mimicking Conventional H. pylori-Associated Atrophic Gastritis
title_short Helicobacter suis-Associated Gastritis Mimicking Conventional H. pylori-Associated Atrophic Gastritis
title_sort helicobacter suis associated gastritis mimicking conventional h pylori associated atrophic gastritis
url http://dx.doi.org/10.1155/2022/4254605
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AT masahikonakamura helicobactersuisassociatedgastritismimickingconventionalhpyloriassociatedatrophicgastritis
AT kentahamada helicobactersuisassociatedgastritismimickingconventionalhpyloriassociatedatrophicgastritis
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