Periampullary Metastases from Breast Cancer: A Case Report and Literature Review
We presented a metastatic breast cancer case who was afflicted with obstructive jaundice caused by an ampullary neoplasm. Since jaundice due to periampullary metastasis from breast cancer was a rare entity, a literature review of similar cases through the PubMed database was done. A total of 23 addi...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/3479568 |
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| author | Yi Lin Sio In Wong Yuzhou Wang Chileong Lam Xianghong Peng |
| author_facet | Yi Lin Sio In Wong Yuzhou Wang Chileong Lam Xianghong Peng |
| author_sort | Yi Lin |
| collection | DOAJ |
| description | We presented a metastatic breast cancer case who was afflicted with obstructive jaundice caused by an ampullary neoplasm. Since jaundice due to periampullary metastasis from breast cancer was a rare entity, a literature review of similar cases through the PubMed database was done. A total of 23 additional cases were found. Among these 24 cases, 5 presented with periampullary metastasis synchronously with the diagnosis of breast cancer, while 19 had metachronous periampullary metastasis with an interval ranging between 1.3 and 23 years from the initial diagnosis of breast cancer to the emergence of jaundice. It is intriguing to establish a differential diagnosis for common bile tract stricture prior to tissue biopsy, even with diagnostic workups including serum tumor markers, MRI plus MRCP, ERCP with intraductal brushing, and endoscopic ultrasound, in that the clinical, radiological, and endoscopic findings of metastatic lesions overlapped extensively with those found with primary periampullary malignancies. An immunohistochemical portfolio including cytokeratin7/20 (CK7/20), homeobox protein CDX2, human epidermal growth factor receptor 2 (HER2/neu), estrogen receptor alfa (ERα), progesterone receptor (PgR), mammaglobin, gross cystic disease fluid protein-15 (GCDFP-15), and transacting T-cell-specific transcription factor (GATA-3) was helpful for differential diagnosis among cases with ambiguous microscopic features. |
| format | Article |
| id | doaj-art-35c8a677b4cf4795a91c0406d59f4cfd |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-35c8a677b4cf4795a91c0406d59f4cfd2025-08-20T03:55:16ZengWileyCase Reports in Oncological Medicine2090-67062090-67142019-01-01201910.1155/2019/34795683479568Periampullary Metastases from Breast Cancer: A Case Report and Literature ReviewYi Lin0Sio In Wong1Yuzhou Wang2Chileong Lam3Xianghong Peng4Department of Medical Oncology, Centro Hospitalar Conde de São Januário, Sé, MacauDepartment of Pathology, Centro Hospitalar Conde de São Januário, Sé, MacauDepartment of Medical Oncology, Centro Hospitalar Conde de São Januário, Sé, MacauDepartment of Medical Oncology, Centro Hospitalar Conde de São Januário, Sé, MacauDepartment of Medical Oncology, Centro Hospitalar Conde de São Januário, Sé, MacauWe presented a metastatic breast cancer case who was afflicted with obstructive jaundice caused by an ampullary neoplasm. Since jaundice due to periampullary metastasis from breast cancer was a rare entity, a literature review of similar cases through the PubMed database was done. A total of 23 additional cases were found. Among these 24 cases, 5 presented with periampullary metastasis synchronously with the diagnosis of breast cancer, while 19 had metachronous periampullary metastasis with an interval ranging between 1.3 and 23 years from the initial diagnosis of breast cancer to the emergence of jaundice. It is intriguing to establish a differential diagnosis for common bile tract stricture prior to tissue biopsy, even with diagnostic workups including serum tumor markers, MRI plus MRCP, ERCP with intraductal brushing, and endoscopic ultrasound, in that the clinical, radiological, and endoscopic findings of metastatic lesions overlapped extensively with those found with primary periampullary malignancies. An immunohistochemical portfolio including cytokeratin7/20 (CK7/20), homeobox protein CDX2, human epidermal growth factor receptor 2 (HER2/neu), estrogen receptor alfa (ERα), progesterone receptor (PgR), mammaglobin, gross cystic disease fluid protein-15 (GCDFP-15), and transacting T-cell-specific transcription factor (GATA-3) was helpful for differential diagnosis among cases with ambiguous microscopic features.http://dx.doi.org/10.1155/2019/3479568 |
| spellingShingle | Yi Lin Sio In Wong Yuzhou Wang Chileong Lam Xianghong Peng Periampullary Metastases from Breast Cancer: A Case Report and Literature Review Case Reports in Oncological Medicine |
| title | Periampullary Metastases from Breast Cancer: A Case Report and Literature Review |
| title_full | Periampullary Metastases from Breast Cancer: A Case Report and Literature Review |
| title_fullStr | Periampullary Metastases from Breast Cancer: A Case Report and Literature Review |
| title_full_unstemmed | Periampullary Metastases from Breast Cancer: A Case Report and Literature Review |
| title_short | Periampullary Metastases from Breast Cancer: A Case Report and Literature Review |
| title_sort | periampullary metastases from breast cancer a case report and literature review |
| url | http://dx.doi.org/10.1155/2019/3479568 |
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