Preclinical Ultrasound-Guided Photoacoustic Imaging of the Placenta in Normal and Pathologic Pregnancy
Placental oxygenation varies throughout pregnancy. The detection of early changes in placental oxygenation as pregnancy progresses is important for early identification of preeclampsia or other complications. This invited commentary discusses a recent preclinical study on the application of 3-dimens...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-10-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012118802721 |
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| author | Liliya M. Yamaleyeva MD, MS, FAHA K. Bridget Brosnihan PhD, FAHA Lane M. Smith MD, PhD Yao Sun PhD |
| author_facet | Liliya M. Yamaleyeva MD, MS, FAHA K. Bridget Brosnihan PhD, FAHA Lane M. Smith MD, PhD Yao Sun PhD |
| author_sort | Liliya M. Yamaleyeva MD, MS, FAHA |
| collection | DOAJ |
| description | Placental oxygenation varies throughout pregnancy. The detection of early changes in placental oxygenation as pregnancy progresses is important for early identification of preeclampsia or other complications. This invited commentary discusses a recent preclinical study on the application of 3-dimensional photoacoustic imaging (PAI) for assessment of regional variations in placental oxygenation and longitudinal analysis of differences in placental oxygenation throughout normal pregnancy and pregnancy associated with hypertension or placental insufficiency in mice. Three-dimensional PAI more accurately reflects oxygen saturation, hemoglobin concentrations, and changes in oxygen saturation in whole placenta compared to 2-dimensional imaging. These studies suggest that PAI is a sensitive tool to detect different levels of oxygen saturation in the placental and fetal vasculature in pathologic and normal pregnancy in mice. |
| format | Article |
| id | doaj-art-35c66aa2f0a34f1fb9c187c2fda888d9 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2018-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-35c66aa2f0a34f1fb9c187c2fda888d92025-01-02T23:37:27ZengSAGE PublishingMolecular Imaging1536-01212018-10-011710.1177/1536012118802721Preclinical Ultrasound-Guided Photoacoustic Imaging of the Placenta in Normal and Pathologic PregnancyLiliya M. Yamaleyeva MD, MS, FAHA0K. Bridget Brosnihan PhD, FAHA1Lane M. Smith MD, PhD2Yao Sun PhD3 Department of Surgery, Hypertension and Vascular Research, Wake Forest School of Medicine, Winston-Salem, NC, USA Department of Surgery, Hypertension and Vascular Research, Wake Forest School of Medicine, Winston-Salem, NC, USA Department of Emergency Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USAPlacental oxygenation varies throughout pregnancy. The detection of early changes in placental oxygenation as pregnancy progresses is important for early identification of preeclampsia or other complications. This invited commentary discusses a recent preclinical study on the application of 3-dimensional photoacoustic imaging (PAI) for assessment of regional variations in placental oxygenation and longitudinal analysis of differences in placental oxygenation throughout normal pregnancy and pregnancy associated with hypertension or placental insufficiency in mice. Three-dimensional PAI more accurately reflects oxygen saturation, hemoglobin concentrations, and changes in oxygen saturation in whole placenta compared to 2-dimensional imaging. These studies suggest that PAI is a sensitive tool to detect different levels of oxygen saturation in the placental and fetal vasculature in pathologic and normal pregnancy in mice.https://doi.org/10.1177/1536012118802721 |
| spellingShingle | Liliya M. Yamaleyeva MD, MS, FAHA K. Bridget Brosnihan PhD, FAHA Lane M. Smith MD, PhD Yao Sun PhD Preclinical Ultrasound-Guided Photoacoustic Imaging of the Placenta in Normal and Pathologic Pregnancy Molecular Imaging |
| title | Preclinical Ultrasound-Guided Photoacoustic Imaging of the Placenta in Normal and Pathologic Pregnancy |
| title_full | Preclinical Ultrasound-Guided Photoacoustic Imaging of the Placenta in Normal and Pathologic Pregnancy |
| title_fullStr | Preclinical Ultrasound-Guided Photoacoustic Imaging of the Placenta in Normal and Pathologic Pregnancy |
| title_full_unstemmed | Preclinical Ultrasound-Guided Photoacoustic Imaging of the Placenta in Normal and Pathologic Pregnancy |
| title_short | Preclinical Ultrasound-Guided Photoacoustic Imaging of the Placenta in Normal and Pathologic Pregnancy |
| title_sort | preclinical ultrasound guided photoacoustic imaging of the placenta in normal and pathologic pregnancy |
| url | https://doi.org/10.1177/1536012118802721 |
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