Evaluation of Retinal Changes in Women with Different Phenotypes of Polycystic Ovary Syndrome
<b>Background</b>: The aim of our study was to evaluate the retinal nerve fiber layer (RNFL) and macular and choroidal thicknesses in women with different phenotypes of polycystic ovary syndrome (PCOS), and compare these measurements with those of healthy women of reproductive age. <b...
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2025-01-01
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| author | Fatma Sumer Beril Gurlek Elif Yildiz Feyzahan Uzun Sabri Colak Ilknur Merve Ayazoglu |
| author_facet | Fatma Sumer Beril Gurlek Elif Yildiz Feyzahan Uzun Sabri Colak Ilknur Merve Ayazoglu |
| author_sort | Fatma Sumer |
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| description | <b>Background</b>: The aim of our study was to evaluate the retinal nerve fiber layer (RNFL) and macular and choroidal thicknesses in women with different phenotypes of polycystic ovary syndrome (PCOS), and compare these measurements with those of healthy women of reproductive age. <b>Materials and Methods</b>: This prospective case–control study included 120 eyes of 120 women with PCOS, with each of the four distinct phenotypes comprising 30 eyes of 30 women. Additionally, 30 eyes from 30 healthy women were included in the control group. All participants underwent comprehensive ophthalmologic examinations, and RNFL thickness, macular thickness (MT), and choroidal thickness (CT) in each eye were measured via spectral-domain optical coherence tomography. The body mass index (BMI) of the patients was recorded and compared with the retinal changes. <b>Results</b>: The average mean and nasal segments of the RNFL were significantly greater in the PCOS group than in the healthy control group (<i>p</i> < 0.001). There was a statistically significant difference in foveal retinal thickness between the groups (<i>p</i> < 0.001). Our study revealed significant choroidal tissue thickening subfoveally and at locations 500 μm temporal, 500 μm nasal, 1500 μm nasal, and 1500 μm temporal to the fovea in all phenotypes of the PCOS group (<i>p</i> < 0.001). Additionally, there was a positive correlation between BMI and all CT changes. <b>Conclusions</b>: Our findings indicate that the retinal layers and choroid are affected by all phenotypes of PCOS, one of the most common reproductive abnormalities, albeit to varying degrees. Furthermore, these changes were found to be correlated with BMI. |
| format | Article |
| id | doaj-art-35c461a79ac04fe28d4491497f7ae234 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-35c461a79ac04fe28d4491497f7ae2342025-01-24T13:29:11ZengMDPI AGDiagnostics2075-44182025-01-0115222710.3390/diagnostics15020227Evaluation of Retinal Changes in Women with Different Phenotypes of Polycystic Ovary SyndromeFatma Sumer0Beril Gurlek1Elif Yildiz2Feyzahan Uzun3Sabri Colak4Ilknur Merve Ayazoglu5Department of Ophthalmology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize 53100, TurkeyDepartment of Obsetrics and Gynaecology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize 53100, TurkeyDepartment of Obsetrics and Gynaecology, İstanbul Gaziosmanpasa Training and Research Hospital, Istanbul 34255, TurkeyDepartment of Ophthalmology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize 53100, TurkeyDepartment of Obsetrics and Gynaecology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize 53100, TurkeyDepartment of Obsetrics and Gynaecology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey<b>Background</b>: The aim of our study was to evaluate the retinal nerve fiber layer (RNFL) and macular and choroidal thicknesses in women with different phenotypes of polycystic ovary syndrome (PCOS), and compare these measurements with those of healthy women of reproductive age. <b>Materials and Methods</b>: This prospective case–control study included 120 eyes of 120 women with PCOS, with each of the four distinct phenotypes comprising 30 eyes of 30 women. Additionally, 30 eyes from 30 healthy women were included in the control group. All participants underwent comprehensive ophthalmologic examinations, and RNFL thickness, macular thickness (MT), and choroidal thickness (CT) in each eye were measured via spectral-domain optical coherence tomography. The body mass index (BMI) of the patients was recorded and compared with the retinal changes. <b>Results</b>: The average mean and nasal segments of the RNFL were significantly greater in the PCOS group than in the healthy control group (<i>p</i> < 0.001). There was a statistically significant difference in foveal retinal thickness between the groups (<i>p</i> < 0.001). Our study revealed significant choroidal tissue thickening subfoveally and at locations 500 μm temporal, 500 μm nasal, 1500 μm nasal, and 1500 μm temporal to the fovea in all phenotypes of the PCOS group (<i>p</i> < 0.001). Additionally, there was a positive correlation between BMI and all CT changes. <b>Conclusions</b>: Our findings indicate that the retinal layers and choroid are affected by all phenotypes of PCOS, one of the most common reproductive abnormalities, albeit to varying degrees. Furthermore, these changes were found to be correlated with BMI.https://www.mdpi.com/2075-4418/15/2/227choroidal thicknessmacular thicknessoptical coherence tomographypolycystic ovary syndromeretinal nerve fiber layer |
| spellingShingle | Fatma Sumer Beril Gurlek Elif Yildiz Feyzahan Uzun Sabri Colak Ilknur Merve Ayazoglu Evaluation of Retinal Changes in Women with Different Phenotypes of Polycystic Ovary Syndrome Diagnostics choroidal thickness macular thickness optical coherence tomography polycystic ovary syndrome retinal nerve fiber layer |
| title | Evaluation of Retinal Changes in Women with Different Phenotypes of Polycystic Ovary Syndrome |
| title_full | Evaluation of Retinal Changes in Women with Different Phenotypes of Polycystic Ovary Syndrome |
| title_fullStr | Evaluation of Retinal Changes in Women with Different Phenotypes of Polycystic Ovary Syndrome |
| title_full_unstemmed | Evaluation of Retinal Changes in Women with Different Phenotypes of Polycystic Ovary Syndrome |
| title_short | Evaluation of Retinal Changes in Women with Different Phenotypes of Polycystic Ovary Syndrome |
| title_sort | evaluation of retinal changes in women with different phenotypes of polycystic ovary syndrome |
| topic | choroidal thickness macular thickness optical coherence tomography polycystic ovary syndrome retinal nerve fiber layer |
| url | https://www.mdpi.com/2075-4418/15/2/227 |
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