DETERMINING THE IMPORTANCE OF GLYCEMIC VARIABILITY IN GESTATIONAL DIABETES MELLITUS USING VARIOUS TECHNIQUES
Objective: The study aims to determine glycemic variation in patients with GDM and to evaluate the effect on the fetal growth using a continuous glucose monitoring system (CGMS) and to investigate the correlation between glucose variation through biomarkers including HbA1c, fructosamine (FRM), and 1...
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| Format: | Article |
| Language: | English |
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Istanbul University Press
2023-01-01
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| Series: | İstanbul Tıp Fakültesi Dergisi |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/2FE6BFA006214F21A68ACB416280C52A |
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| author | Nida Öztop Ayşe Kubat Üzüm Selda Çelik Cemile İdiz Yıldız Tütüncü Elif Bağdemir Nevin Dinççağ |
| author_facet | Nida Öztop Ayşe Kubat Üzüm Selda Çelik Cemile İdiz Yıldız Tütüncü Elif Bağdemir Nevin Dinççağ |
| author_sort | Nida Öztop |
| collection | DOAJ |
| description | Objective: The study aims to determine glycemic variation in patients with GDM and to evaluate the effect on the fetal growth using a continuous glucose monitoring system (CGMS) and to investigate the correlation between glucose variation through biomarkers including HbA1c, fructosamine (FRM), and 1.5-Anhydroglucitol (1.5-AG). Materials and Methods: The study involves 31 women with GDM at gestational week ≥35 who’d only had diet therapy. Blood glucose levels were monitored for three consecutive days using CGMS to evaluate mean blood glucose levels and mean absolute difference (MAD). Self-monitoring of blood glucose (SMBG) was required from the patients while having the CMGS on their body. Blood samples were collected to measure serum 1.5-AG, HbA1c, and FRM. Results: The mean levels were HbA1c=5.0±0.3%, FRM=2.1±0.2 μmol/L, 1.5-AG=17.0±4.9 ng/ml, and 3-day average max-min glucose range=131.1±22.5 and 54.7±11.6 mg/dl (MAD=6.7±3.1%). The mean glucose levels measured using SMBG and CGMS were similar (82.9±10.2 vs 86.1±10.3 mg/dL). No correlation occurred between CMGS and biomarkers. The baby weight at birth and head circumference was determined to be lower for patients with glucose fluctuations. Conclusion: Biomarkers do not reflect glycemic fluctuation, and regular SMBG is required to achieve the desired glucose level, even in diet-regulated GDM. Lower head circumference and birth weight were determined in GDM mothers with high glycemic fluctuations, and CGMS may be an alternative method despite its cost and application difficulties. |
| format | Article |
| id | doaj-art-35c335a4d3074c60a2a520ecd9a48974 |
| institution | Kabale University |
| issn | 1305-6441 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | İstanbul Tıp Fakültesi Dergisi |
| spelling | doaj-art-35c335a4d3074c60a2a520ecd9a489742025-08-20T03:52:47ZengIstanbul University Pressİstanbul Tıp Fakültesi Dergisi1305-64412023-01-01861445110.26650/IUITFD.1193997123456DETERMINING THE IMPORTANCE OF GLYCEMIC VARIABILITY IN GESTATIONAL DIABETES MELLITUS USING VARIOUS TECHNIQUESNida Öztop0https://orcid.org/0000-0003-2607-3833Ayşe Kubat Üzüm1https://orcid.org/0000-0003-0478-1193Selda Çelik2https://orcid.org/0000-0003-4328-3189Cemile İdiz3https://orcid.org/0000-0001-6635-5996Yıldız Tütüncü4https://orcid.org/0000-0002-3905-6429Elif Bağdemir5https://orcid.org/0000-0002-0035-6360Nevin Dinççağ6https://orcid.org/0000-0003-3986-4546Sağlık Bakanlığı, Ankara, Turkiyeİstanbul Üniversitesi, İstanbul, TürkiyeSağlık Bilimleri Üniversitesi, Istanbul, Turkiyeİstanbul Üniversitesi, İstanbul, TürkiyeKoç Üniversitesi, Istanbul, Turkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, TürkiyeObjective: The study aims to determine glycemic variation in patients with GDM and to evaluate the effect on the fetal growth using a continuous glucose monitoring system (CGMS) and to investigate the correlation between glucose variation through biomarkers including HbA1c, fructosamine (FRM), and 1.5-Anhydroglucitol (1.5-AG). Materials and Methods: The study involves 31 women with GDM at gestational week ≥35 who’d only had diet therapy. Blood glucose levels were monitored for three consecutive days using CGMS to evaluate mean blood glucose levels and mean absolute difference (MAD). Self-monitoring of blood glucose (SMBG) was required from the patients while having the CMGS on their body. Blood samples were collected to measure serum 1.5-AG, HbA1c, and FRM. Results: The mean levels were HbA1c=5.0±0.3%, FRM=2.1±0.2 μmol/L, 1.5-AG=17.0±4.9 ng/ml, and 3-day average max-min glucose range=131.1±22.5 and 54.7±11.6 mg/dl (MAD=6.7±3.1%). The mean glucose levels measured using SMBG and CGMS were similar (82.9±10.2 vs 86.1±10.3 mg/dL). No correlation occurred between CMGS and biomarkers. The baby weight at birth and head circumference was determined to be lower for patients with glucose fluctuations. Conclusion: Biomarkers do not reflect glycemic fluctuation, and regular SMBG is required to achieve the desired glucose level, even in diet-regulated GDM. Lower head circumference and birth weight were determined in GDM mothers with high glycemic fluctuations, and CGMS may be an alternative method despite its cost and application difficulties.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/2FE6BFA006214F21A68ACB416280C52Agestational diabetes1.5-anhydroglucitolglycemic variabilityhba1cfructosamine |
| spellingShingle | Nida Öztop Ayşe Kubat Üzüm Selda Çelik Cemile İdiz Yıldız Tütüncü Elif Bağdemir Nevin Dinççağ DETERMINING THE IMPORTANCE OF GLYCEMIC VARIABILITY IN GESTATIONAL DIABETES MELLITUS USING VARIOUS TECHNIQUES İstanbul Tıp Fakültesi Dergisi gestational diabetes 1.5-anhydroglucitol glycemic variability hba1c fructosamine |
| title | DETERMINING THE IMPORTANCE OF GLYCEMIC VARIABILITY IN GESTATIONAL DIABETES MELLITUS USING VARIOUS TECHNIQUES |
| title_full | DETERMINING THE IMPORTANCE OF GLYCEMIC VARIABILITY IN GESTATIONAL DIABETES MELLITUS USING VARIOUS TECHNIQUES |
| title_fullStr | DETERMINING THE IMPORTANCE OF GLYCEMIC VARIABILITY IN GESTATIONAL DIABETES MELLITUS USING VARIOUS TECHNIQUES |
| title_full_unstemmed | DETERMINING THE IMPORTANCE OF GLYCEMIC VARIABILITY IN GESTATIONAL DIABETES MELLITUS USING VARIOUS TECHNIQUES |
| title_short | DETERMINING THE IMPORTANCE OF GLYCEMIC VARIABILITY IN GESTATIONAL DIABETES MELLITUS USING VARIOUS TECHNIQUES |
| title_sort | determining the importance of glycemic variability in gestational diabetes mellitus using various techniques |
| topic | gestational diabetes 1.5-anhydroglucitol glycemic variability hba1c fructosamine |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/2FE6BFA006214F21A68ACB416280C52A |
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