Role of Age, Comorbidity, and Frailty in the Prediction of Postoperative Complications After Surgery for Vulvar Cancer: A Retrospective Cohort Study with the Development of a Nomogram
Surgery is the cornerstone of vulvar cancer treatment, but it is associated with a significant risk of complications that may impact prognosis, particularly in older patients with multiple comorbidities. The objective of this study was to evaluate the role of age, comorbidities, and frailty in predi...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/32/1/21 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588687329722368 |
|---|---|
| author | Giovanni Delli Carpini Francesco Sopracordevole Camilla Cicoli Marco Bernardi Lucia Giuliani Mariasole Fichera Nicolò Clemente Anna Del Fabro Jacopo Di Giuseppe Luca Giannella Enrico Busato Andrea Ciavattini |
| author_facet | Giovanni Delli Carpini Francesco Sopracordevole Camilla Cicoli Marco Bernardi Lucia Giuliani Mariasole Fichera Nicolò Clemente Anna Del Fabro Jacopo Di Giuseppe Luca Giannella Enrico Busato Andrea Ciavattini |
| author_sort | Giovanni Delli Carpini |
| collection | DOAJ |
| description | Surgery is the cornerstone of vulvar cancer treatment, but it is associated with a significant risk of complications that may impact prognosis, particularly in older patients with multiple comorbidities. The objective of this study was to evaluate the role of age, comorbidities, and frailty in predicting postoperative complications after vulvar cancer surgery and to develop a predictive nomogram. A retrospective cohort study was conducted, including patients who underwent surgery for vulvar cancer at two Italian institutions from January 2018 to December 2023. A logistic regression model for the rate of Clavien-Dindo 2+ 30-days complications was run, considering the age-adjusted Charlson Comorbidity Index (AACCI), body mass index (BMI), and frailty as exposures. Lesion characteristics and surgical procedures were considered as confounders. Among the 225 included patients, 50 (22.2%) had a grade 2+ complication. The predictive score of the nomogram ranged from 44 to 140. The AACCI (0–64 points) and BMI (0–100 points) were independently associated with a risk of complications. A nomogram including the AACCI and BMI predicts the risk of complications for patients undergoing surgery for vulvar cancer. The preoperative determination of the risk of complications enables surgical planning and allows a tailored peri- and postoperative management plan. |
| format | Article |
| id | doaj-art-35b929422a6940b084eb6e67b6e80c3e |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-35b929422a6940b084eb6e67b6e80c3e2025-01-24T13:28:23ZengMDPI AGCurrent Oncology1198-00521718-77292024-12-013212110.3390/curroncol32010021Role of Age, Comorbidity, and Frailty in the Prediction of Postoperative Complications After Surgery for Vulvar Cancer: A Retrospective Cohort Study with the Development of a NomogramGiovanni Delli Carpini0Francesco Sopracordevole1Camilla Cicoli2Marco Bernardi3Lucia Giuliani4Mariasole Fichera5Nicolò Clemente6Anna Del Fabro7Jacopo Di Giuseppe8Luca Giannella9Enrico Busato10Andrea Ciavattini11Gynecologic Section, Department of Odontostomatologic and Specialized Clinical Sciences, Università Politecnica delle Marche, 60131 Ancona, ItalyGynecological Oncology Unit, IRCCS CRO, Centro di Riferimento Oncologico, National Cancer Institute, 33081 Aviano, ItalyGynecologic Section, Department of Odontostomatologic and Specialized Clinical Sciences, Università Politecnica delle Marche, 60131 Ancona, ItalyGynecologic Section, Department of Odontostomatologic and Specialized Clinical Sciences, Università Politecnica delle Marche, 60131 Ancona, ItalyGynecologic Section, Department of Odontostomatologic and Specialized Clinical Sciences, Università Politecnica delle Marche, 60131 Ancona, ItalyGynecologic Section, Department of Odontostomatologic and Specialized Clinical Sciences, Università Politecnica delle Marche, 60131 Ancona, ItalyGynecological Oncology Unit, IRCCS CRO, Centro di Riferimento Oncologico, National Cancer Institute, 33081 Aviano, ItalyGynecological Oncology Unit, IRCCS CRO, Centro di Riferimento Oncologico, National Cancer Institute, 33081 Aviano, ItalyGynecologic Section, Department of Odontostomatologic and Specialized Clinical Sciences, Università Politecnica delle Marche, 60131 Ancona, ItalyGynecologic Section, Department of Odontostomatologic and Specialized Clinical Sciences, Università Politecnica delle Marche, 60131 Ancona, ItalyDepartment of Gynaecology and Obstetrics, Treviso Regional Hospital, AULSS 2 Marca Trevigiana, Piazzale Ospedale 1, 31100 Treviso, ItalyGynecologic Section, Department of Odontostomatologic and Specialized Clinical Sciences, Università Politecnica delle Marche, 60131 Ancona, ItalySurgery is the cornerstone of vulvar cancer treatment, but it is associated with a significant risk of complications that may impact prognosis, particularly in older patients with multiple comorbidities. The objective of this study was to evaluate the role of age, comorbidities, and frailty in predicting postoperative complications after vulvar cancer surgery and to develop a predictive nomogram. A retrospective cohort study was conducted, including patients who underwent surgery for vulvar cancer at two Italian institutions from January 2018 to December 2023. A logistic regression model for the rate of Clavien-Dindo 2+ 30-days complications was run, considering the age-adjusted Charlson Comorbidity Index (AACCI), body mass index (BMI), and frailty as exposures. Lesion characteristics and surgical procedures were considered as confounders. Among the 225 included patients, 50 (22.2%) had a grade 2+ complication. The predictive score of the nomogram ranged from 44 to 140. The AACCI (0–64 points) and BMI (0–100 points) were independently associated with a risk of complications. A nomogram including the AACCI and BMI predicts the risk of complications for patients undergoing surgery for vulvar cancer. The preoperative determination of the risk of complications enables surgical planning and allows a tailored peri- and postoperative management plan.https://www.mdpi.com/1718-7729/32/1/21vulvar neoplasmssurgerypostoperative complicationscomorbidityfrailtyprognosis |
| spellingShingle | Giovanni Delli Carpini Francesco Sopracordevole Camilla Cicoli Marco Bernardi Lucia Giuliani Mariasole Fichera Nicolò Clemente Anna Del Fabro Jacopo Di Giuseppe Luca Giannella Enrico Busato Andrea Ciavattini Role of Age, Comorbidity, and Frailty in the Prediction of Postoperative Complications After Surgery for Vulvar Cancer: A Retrospective Cohort Study with the Development of a Nomogram Current Oncology vulvar neoplasms surgery postoperative complications comorbidity frailty prognosis |
| title | Role of Age, Comorbidity, and Frailty in the Prediction of Postoperative Complications After Surgery for Vulvar Cancer: A Retrospective Cohort Study with the Development of a Nomogram |
| title_full | Role of Age, Comorbidity, and Frailty in the Prediction of Postoperative Complications After Surgery for Vulvar Cancer: A Retrospective Cohort Study with the Development of a Nomogram |
| title_fullStr | Role of Age, Comorbidity, and Frailty in the Prediction of Postoperative Complications After Surgery for Vulvar Cancer: A Retrospective Cohort Study with the Development of a Nomogram |
| title_full_unstemmed | Role of Age, Comorbidity, and Frailty in the Prediction of Postoperative Complications After Surgery for Vulvar Cancer: A Retrospective Cohort Study with the Development of a Nomogram |
| title_short | Role of Age, Comorbidity, and Frailty in the Prediction of Postoperative Complications After Surgery for Vulvar Cancer: A Retrospective Cohort Study with the Development of a Nomogram |
| title_sort | role of age comorbidity and frailty in the prediction of postoperative complications after surgery for vulvar cancer a retrospective cohort study with the development of a nomogram |
| topic | vulvar neoplasms surgery postoperative complications comorbidity frailty prognosis |
| url | https://www.mdpi.com/1718-7729/32/1/21 |
| work_keys_str_mv | AT giovannidellicarpini roleofagecomorbidityandfrailtyinthepredictionofpostoperativecomplicationsaftersurgeryforvulvarcanceraretrospectivecohortstudywiththedevelopmentofanomogram AT francescosopracordevole roleofagecomorbidityandfrailtyinthepredictionofpostoperativecomplicationsaftersurgeryforvulvarcanceraretrospectivecohortstudywiththedevelopmentofanomogram AT camillacicoli roleofagecomorbidityandfrailtyinthepredictionofpostoperativecomplicationsaftersurgeryforvulvarcanceraretrospectivecohortstudywiththedevelopmentofanomogram AT marcobernardi roleofagecomorbidityandfrailtyinthepredictionofpostoperativecomplicationsaftersurgeryforvulvarcanceraretrospectivecohortstudywiththedevelopmentofanomogram AT luciagiuliani roleofagecomorbidityandfrailtyinthepredictionofpostoperativecomplicationsaftersurgeryforvulvarcanceraretrospectivecohortstudywiththedevelopmentofanomogram AT mariasolefichera roleofagecomorbidityandfrailtyinthepredictionofpostoperativecomplicationsaftersurgeryforvulvarcanceraretrospectivecohortstudywiththedevelopmentofanomogram AT nicoloclemente roleofagecomorbidityandfrailtyinthepredictionofpostoperativecomplicationsaftersurgeryforvulvarcanceraretrospectivecohortstudywiththedevelopmentofanomogram AT annadelfabro roleofagecomorbidityandfrailtyinthepredictionofpostoperativecomplicationsaftersurgeryforvulvarcanceraretrospectivecohortstudywiththedevelopmentofanomogram AT jacopodigiuseppe roleofagecomorbidityandfrailtyinthepredictionofpostoperativecomplicationsaftersurgeryforvulvarcanceraretrospectivecohortstudywiththedevelopmentofanomogram AT lucagiannella roleofagecomorbidityandfrailtyinthepredictionofpostoperativecomplicationsaftersurgeryforvulvarcanceraretrospectivecohortstudywiththedevelopmentofanomogram AT enricobusato roleofagecomorbidityandfrailtyinthepredictionofpostoperativecomplicationsaftersurgeryforvulvarcanceraretrospectivecohortstudywiththedevelopmentofanomogram AT andreaciavattini roleofagecomorbidityandfrailtyinthepredictionofpostoperativecomplicationsaftersurgeryforvulvarcanceraretrospectivecohortstudywiththedevelopmentofanomogram |