Analysis of arterial stiffness parameters in breast cancer patients undergoing combination anthracycline-containing chemotherapy
Aim. To identify and analyze changes of arterial stiffness (AS) parameters in breast cancer patients undergoing combination anthracycline-containing chemotherapy (ACCT).Material and methods. Fifty women with verified breast cancer aged 46,7±7 years with indications for combined ACCT were assessed fo...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2025-05-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/4272 |
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| author | E. G. Medvedeva E. N. Yushchuk S. V. Ivanova D. A. Filonenko L. G. Zhukova O. S. Trofimenko |
| author_facet | E. G. Medvedeva E. N. Yushchuk S. V. Ivanova D. A. Filonenko L. G. Zhukova O. S. Trofimenko |
| author_sort | E. G. Medvedeva |
| collection | DOAJ |
| description | Aim. To identify and analyze changes of arterial stiffness (AS) parameters in breast cancer patients undergoing combination anthracycline-containing chemotherapy (ACCT).Material and methods. Fifty women with verified breast cancer aged 46,7±7 years with indications for combined ACCT were assessed for AS (carotid-femoral pulse wave velocity (cfPWV) (m/s); cardio-ankle vascular index (CAVI); cardio-ankle pulse wave velocity (caPWV) (m/s); β-stiffness index, novel Russian Stelari and haStart indices) at 4 visits as follows: before ACCT, after 8-12, 20-24 and 48 weeks from the ACCT start.Results. A reliable decrease in cfPWV was revealed at visit 2 (7,48±1,51, p<0,05) and visit 3 (8,34±1,66, p<0,05) with further significant increase at visit 4 when compared with baseline data. Similar reliable changes were demonstrated for the Stelari index. CAVI decreased at visits 2 and 3 with a reliable difference from the values at visits 1 and 4. No reliable changes in β and haStart stiffness indices were obtained during the follow-up period.Conclusion. In patients with breast cancer who underwent combined ACCT, an increase in cfPWV by 0,95 m/s per year was revealed, which indicates accelerated vascular wall aging and a possible increase in cardiovascular risk in this category of patients. |
| format | Article |
| id | doaj-art-35b640ac63aa4e3da5db2bb2e7b09570 |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2025-05-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-35b640ac63aa4e3da5db2bb2e7b095702025-08-20T03:57:19Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252025-05-0124410.15829/1728-8800-2025-42723210Analysis of arterial stiffness parameters in breast cancer patients undergoing combination anthracycline-containing chemotherapyE. G. Medvedeva0E. N. Yushchuk1S. V. Ivanova2D. A. Filonenko3L. G. Zhukova4O. S. Trofimenko5Russian University of MedicineRussian University of MedicineRussian University of MedicineLoginov Moscow Clinical Scientific and Practical CenterLoginov Moscow Clinical Scientific and Practical CenterRussian University of MedicineAim. To identify and analyze changes of arterial stiffness (AS) parameters in breast cancer patients undergoing combination anthracycline-containing chemotherapy (ACCT).Material and methods. Fifty women with verified breast cancer aged 46,7±7 years with indications for combined ACCT were assessed for AS (carotid-femoral pulse wave velocity (cfPWV) (m/s); cardio-ankle vascular index (CAVI); cardio-ankle pulse wave velocity (caPWV) (m/s); β-stiffness index, novel Russian Stelari and haStart indices) at 4 visits as follows: before ACCT, after 8-12, 20-24 and 48 weeks from the ACCT start.Results. A reliable decrease in cfPWV was revealed at visit 2 (7,48±1,51, p<0,05) and visit 3 (8,34±1,66, p<0,05) with further significant increase at visit 4 when compared with baseline data. Similar reliable changes were demonstrated for the Stelari index. CAVI decreased at visits 2 and 3 with a reliable difference from the values at visits 1 and 4. No reliable changes in β and haStart stiffness indices were obtained during the follow-up period.Conclusion. In patients with breast cancer who underwent combined ACCT, an increase in cfPWV by 0,95 m/s per year was revealed, which indicates accelerated vascular wall aging and a possible increase in cardiovascular risk in this category of patients.https://cardiovascular.elpub.ru/jour/article/view/4272breast cancerarterial stiffnesscarotid-femoral pulse wave velocitycardio-ankle vascular indexstelari indexanthracycline-containing chemotherapy |
| spellingShingle | E. G. Medvedeva E. N. Yushchuk S. V. Ivanova D. A. Filonenko L. G. Zhukova O. S. Trofimenko Analysis of arterial stiffness parameters in breast cancer patients undergoing combination anthracycline-containing chemotherapy Кардиоваскулярная терапия и профилактика breast cancer arterial stiffness carotid-femoral pulse wave velocity cardio-ankle vascular index stelari index anthracycline-containing chemotherapy |
| title | Analysis of arterial stiffness parameters in breast cancer patients undergoing combination anthracycline-containing chemotherapy |
| title_full | Analysis of arterial stiffness parameters in breast cancer patients undergoing combination anthracycline-containing chemotherapy |
| title_fullStr | Analysis of arterial stiffness parameters in breast cancer patients undergoing combination anthracycline-containing chemotherapy |
| title_full_unstemmed | Analysis of arterial stiffness parameters in breast cancer patients undergoing combination anthracycline-containing chemotherapy |
| title_short | Analysis of arterial stiffness parameters in breast cancer patients undergoing combination anthracycline-containing chemotherapy |
| title_sort | analysis of arterial stiffness parameters in breast cancer patients undergoing combination anthracycline containing chemotherapy |
| topic | breast cancer arterial stiffness carotid-femoral pulse wave velocity cardio-ankle vascular index stelari index anthracycline-containing chemotherapy |
| url | https://cardiovascular.elpub.ru/jour/article/view/4272 |
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