Consensus Clustering and Survival-Related Genes of Cuproptosis in Cutaneous Melanoma
As a highly malignant tumor, the morbidity and mortality of cutaneous melanoma (CM) are increasing year by year. A novel type of cell death connected to mitochondrial metabolism is called cuproptosis. Cuproptosis regulates tumor biological behavior. Thus, genes controlling cuproptosis could be a pro...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2023/3615688 |
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| author | Wentao Qin Fu Gan Yiji Jike Mingyang Jiang Ang Li |
| author_facet | Wentao Qin Fu Gan Yiji Jike Mingyang Jiang Ang Li |
| author_sort | Wentao Qin |
| collection | DOAJ |
| description | As a highly malignant tumor, the morbidity and mortality of cutaneous melanoma (CM) are increasing year by year. A novel type of cell death connected to mitochondrial metabolism is called cuproptosis. Cuproptosis regulates tumor biological behavior. Thus, genes controlling cuproptosis could be a promising candidate bioindicator for cancer therapy. Datasets of CM patients were obtained from the public database that includes clinical information and RNA-seq data. We divided CM patients into three different subgroups by unsupervised clustering method and explored the differences in functional pathways among the three subgroups by GSVA to prove the possible potential mechanism of copper death-related genes in the formation and development of CM. Secondly, we used differential analysis and Cox regression analysis to find the differential genes related to prognosis, constructed the CRG score, found the critical score for dividing high and low CRG score groups, and then analyzed the prognosis and immune infiltration of high and low CRG score groups. The results show a great correlation between OS and CRG scores. Compared with patients with high CRG scores, patients with low CRG scores have a significantly higher survival rate. In a word, copper sagging plays a certain role in the progress of CM. |
| format | Article |
| id | doaj-art-35b5bc1251574004b7fca96545bf7629 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-35b5bc1251574004b7fca96545bf76292025-02-03T01:30:25ZengWileyMediators of Inflammation1466-18612023-01-01202310.1155/2023/3615688Consensus Clustering and Survival-Related Genes of Cuproptosis in Cutaneous MelanomaWentao Qin0Fu Gan1Yiji Jike2Mingyang Jiang3Ang Li4Department of OrthopaedicsDepartment of Urology SurgeryDepartment of Bone and Joint SurgeryDepartment of Bone and Joint SurgeryEmergency CenterAs a highly malignant tumor, the morbidity and mortality of cutaneous melanoma (CM) are increasing year by year. A novel type of cell death connected to mitochondrial metabolism is called cuproptosis. Cuproptosis regulates tumor biological behavior. Thus, genes controlling cuproptosis could be a promising candidate bioindicator for cancer therapy. Datasets of CM patients were obtained from the public database that includes clinical information and RNA-seq data. We divided CM patients into three different subgroups by unsupervised clustering method and explored the differences in functional pathways among the three subgroups by GSVA to prove the possible potential mechanism of copper death-related genes in the formation and development of CM. Secondly, we used differential analysis and Cox regression analysis to find the differential genes related to prognosis, constructed the CRG score, found the critical score for dividing high and low CRG score groups, and then analyzed the prognosis and immune infiltration of high and low CRG score groups. The results show a great correlation between OS and CRG scores. Compared with patients with high CRG scores, patients with low CRG scores have a significantly higher survival rate. In a word, copper sagging plays a certain role in the progress of CM.http://dx.doi.org/10.1155/2023/3615688 |
| spellingShingle | Wentao Qin Fu Gan Yiji Jike Mingyang Jiang Ang Li Consensus Clustering and Survival-Related Genes of Cuproptosis in Cutaneous Melanoma Mediators of Inflammation |
| title | Consensus Clustering and Survival-Related Genes of Cuproptosis in Cutaneous Melanoma |
| title_full | Consensus Clustering and Survival-Related Genes of Cuproptosis in Cutaneous Melanoma |
| title_fullStr | Consensus Clustering and Survival-Related Genes of Cuproptosis in Cutaneous Melanoma |
| title_full_unstemmed | Consensus Clustering and Survival-Related Genes of Cuproptosis in Cutaneous Melanoma |
| title_short | Consensus Clustering and Survival-Related Genes of Cuproptosis in Cutaneous Melanoma |
| title_sort | consensus clustering and survival related genes of cuproptosis in cutaneous melanoma |
| url | http://dx.doi.org/10.1155/2023/3615688 |
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