A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production
Development of multiple agents has a significant impact on the cancer diagnosis and therapy. Several fluorescent dyes including near-infrared (NIR) fluorescent agents have been already well studied in the field of photodynamic therapy (PDT). In the present study, we reported a novel fluorescent dye...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2021/4763944 |
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| author | Bei-Bei Zhang Jun-gang Liu Xian-Yu Bai Yuan-Jiao Huang Ning Xu Tao Ren |
| author_facet | Bei-Bei Zhang Jun-gang Liu Xian-Yu Bai Yuan-Jiao Huang Ning Xu Tao Ren |
| author_sort | Bei-Bei Zhang |
| collection | DOAJ |
| description | Development of multiple agents has a significant impact on the cancer diagnosis and therapy. Several fluorescent dyes including near-infrared (NIR) fluorescent agents have been already well studied in the field of photodynamic therapy (PDT). In the present study, we reported a novel fluorescent dye could obviously inhibit cancer cell proliferation with slight toxic effects on the biological organism. Furthermore, it displayed selective staining on cancer cells, particularly on cancer stem cells (CSCs), rather than normal cells. Mechanically, this dye preferred to invading mitochondria of cancer cells and inducing overwhelming reactive oxygen species (ROS) production. The in vivo experiments further demonstrated that this dye could image cancer cells and even CSCs in a short-time intratumor injection manner using a zebrafish model and subsequently inhibit cancer cell proliferation after a relatively long-time drug exposure. Taken together, the future development of this agent will promise to make an essential contribution to the cancer diagnosis and therapeutics. |
| format | Article |
| id | doaj-art-35b59ce003e940dfba71cbe048810a8f |
| institution | OA Journals |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-35b59ce003e940dfba71cbe048810a8f2025-08-20T02:24:07ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2021-01-01202110.1155/2021/47639444763944A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS ProductionBei-Bei Zhang0Jun-gang Liu1Xian-Yu Bai2Yuan-Jiao Huang3Ning Xu4Tao Ren5Institute of Biomedical Research, Yunnan University, Kunming, ChinaGuangxi Medical University Affiliated Cancer Hospital, Nanning, ChinaGraduate School, Guangxi Medical University, Nanning, ChinaLife Science Institute, Guangxi Medical University, Nanning, ChinaThe Fifth Affiliated Hospital of Guangxi Medical University, Nanning, ChinaThe Fifth Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDevelopment of multiple agents has a significant impact on the cancer diagnosis and therapy. Several fluorescent dyes including near-infrared (NIR) fluorescent agents have been already well studied in the field of photodynamic therapy (PDT). In the present study, we reported a novel fluorescent dye could obviously inhibit cancer cell proliferation with slight toxic effects on the biological organism. Furthermore, it displayed selective staining on cancer cells, particularly on cancer stem cells (CSCs), rather than normal cells. Mechanically, this dye preferred to invading mitochondria of cancer cells and inducing overwhelming reactive oxygen species (ROS) production. The in vivo experiments further demonstrated that this dye could image cancer cells and even CSCs in a short-time intratumor injection manner using a zebrafish model and subsequently inhibit cancer cell proliferation after a relatively long-time drug exposure. Taken together, the future development of this agent will promise to make an essential contribution to the cancer diagnosis and therapeutics.http://dx.doi.org/10.1155/2021/4763944 |
| spellingShingle | Bei-Bei Zhang Jun-gang Liu Xian-Yu Bai Yuan-Jiao Huang Ning Xu Tao Ren A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production Bioinorganic Chemistry and Applications |
| title | A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production |
| title_full | A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production |
| title_fullStr | A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production |
| title_full_unstemmed | A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production |
| title_short | A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production |
| title_sort | novel fluorescent dye invades mitochondria to selectively kill cancer stem cells via increased ros production |
| url | http://dx.doi.org/10.1155/2021/4763944 |
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