CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants.

CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants.

Caenorhabditis elegans CEP-1 and its mammalian homolog p53 are critical for responding to diverse stress signals. In this study, we found that cep-1 inactivation suppressed the prolonged lifespan of electron transport chain (ETC) mutants, such as isp-1 and nuo-6, but rescued the shortened lifespan o...

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Main Authors: Aiswarya Baruah, Hsinwen Chang, Mathew Hall, Jie Yuan, Sarah Gordon, Erik Johnson, Ludmila L Shtessel, Callista Yee, Siegfried Hekimi, W Brent Derry, Siu Sylvia Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-02-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004097&type=printable
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