Neural Correlates of Irritability and Potential Moderating Effects of Inhibitory Control
Background: Irritability affects up to 20% of youth and is a primary reason for referral to pediatric mental health clinics. Irritability is thought to be associated with disruptions in processing of reward, threat, and cognitive control; however, empirical study of these associations at both the be...
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Elsevier
2025-03-01
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| Series: | Biological Psychiatry Global Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667174324001332 |
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| author | Mariah DeSerisy Jacob W. Cohen Huiyu Yang Bruce Ramphal Paige Greenwood Kahini Mehta Michael P. Milham Theodore D. Satterthwaite David Pagliaccio Amy E. Margolis |
| author_facet | Mariah DeSerisy Jacob W. Cohen Huiyu Yang Bruce Ramphal Paige Greenwood Kahini Mehta Michael P. Milham Theodore D. Satterthwaite David Pagliaccio Amy E. Margolis |
| author_sort | Mariah DeSerisy |
| collection | DOAJ |
| description | Background: Irritability affects up to 20% of youth and is a primary reason for referral to pediatric mental health clinics. Irritability is thought to be associated with disruptions in processing of reward, threat, and cognitive control; however, empirical study of these associations at both the behavioral and neural level have yielded equivocal findings that may be driven by small sample sizes and differences in study design. Associations between irritability and brain connectivity between cognitive control and reward- or threat-processing circuits remain understudied. Furthermore, better inhibitory control has been linked to lower irritability and differential neural functioning among irritable youth, suggesting that good inhibitory control may serve as a protective factor. Methods: We hypothesized that higher irritability scores would be associated with less positive (or negative) connectivity between cognitive control and threat-processing circuits and between cognitive control and reward-processing circuits in the Healthy Brain Network dataset (release 10.0; N = 4135). We also hypothesized that these associations would be moderated by inhibitory control such that weaker associations between irritability and connectivity would be detected in youths with better than with worse inhibitory control. Regression models were used to test whether associations between irritability and between-network connectivity were moderated by inhibitory control. Results: Counter to our hypothesis, we detected higher irritability associated with reduced connectivity between threat- and reward-processing and cognitive control networks only in 5- to 9-year-old boys. Inhibitory control did not moderate associations of irritability with between-network connectivity. Conclusions: Exploratory findings indicate that reduced between-network connectivity may underlie difficulty regulating negative emotions, leading to greater irritability. |
| format | Article |
| id | doaj-art-35aac57c124747f9a70583245232041b |
| institution | Kabale University |
| issn | 2667-1743 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biological Psychiatry Global Open Science |
| spelling | doaj-art-35aac57c124747f9a70583245232041b2025-01-05T04:28:49ZengElsevierBiological Psychiatry Global Open Science2667-17432025-03-0152100420Neural Correlates of Irritability and Potential Moderating Effects of Inhibitory ControlMariah DeSerisy0Jacob W. Cohen1Huiyu Yang2Bruce Ramphal3Paige Greenwood4Kahini Mehta5Michael P. Milham6Theodore D. Satterthwaite7David Pagliaccio8Amy E. Margolis9Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Address correspondence to Mariah DeSerisy, Ph.D.Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, New YorkDivision of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, New YorkHarvard Medical School, Boston, MassachusettsDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, New YorkDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania; Lifespan Informatics & Neuroimaging Center, University of Pennsylvania, Philadelphia, PennsylvaniaCenter for the Developing Brain, Child Mind Institute, New York, New York; Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New YorkDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania; Lifespan Informatics & Neuroimaging Center, University of Pennsylvania, Philadelphia, PennsylvaniaDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, New YorkDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, New YorkBackground: Irritability affects up to 20% of youth and is a primary reason for referral to pediatric mental health clinics. Irritability is thought to be associated with disruptions in processing of reward, threat, and cognitive control; however, empirical study of these associations at both the behavioral and neural level have yielded equivocal findings that may be driven by small sample sizes and differences in study design. Associations between irritability and brain connectivity between cognitive control and reward- or threat-processing circuits remain understudied. Furthermore, better inhibitory control has been linked to lower irritability and differential neural functioning among irritable youth, suggesting that good inhibitory control may serve as a protective factor. Methods: We hypothesized that higher irritability scores would be associated with less positive (or negative) connectivity between cognitive control and threat-processing circuits and between cognitive control and reward-processing circuits in the Healthy Brain Network dataset (release 10.0; N = 4135). We also hypothesized that these associations would be moderated by inhibitory control such that weaker associations between irritability and connectivity would be detected in youths with better than with worse inhibitory control. Regression models were used to test whether associations between irritability and between-network connectivity were moderated by inhibitory control. Results: Counter to our hypothesis, we detected higher irritability associated with reduced connectivity between threat- and reward-processing and cognitive control networks only in 5- to 9-year-old boys. Inhibitory control did not moderate associations of irritability with between-network connectivity. Conclusions: Exploratory findings indicate that reduced between-network connectivity may underlie difficulty regulating negative emotions, leading to greater irritability.http://www.sciencedirect.com/science/article/pii/S2667174324001332Cognitive controlInhibitory controlIrritabilityNetwork-based analysesReward processingThreat processing |
| spellingShingle | Mariah DeSerisy Jacob W. Cohen Huiyu Yang Bruce Ramphal Paige Greenwood Kahini Mehta Michael P. Milham Theodore D. Satterthwaite David Pagliaccio Amy E. Margolis Neural Correlates of Irritability and Potential Moderating Effects of Inhibitory Control Biological Psychiatry Global Open Science Cognitive control Inhibitory control Irritability Network-based analyses Reward processing Threat processing |
| title | Neural Correlates of Irritability and Potential Moderating Effects of Inhibitory Control |
| title_full | Neural Correlates of Irritability and Potential Moderating Effects of Inhibitory Control |
| title_fullStr | Neural Correlates of Irritability and Potential Moderating Effects of Inhibitory Control |
| title_full_unstemmed | Neural Correlates of Irritability and Potential Moderating Effects of Inhibitory Control |
| title_short | Neural Correlates of Irritability and Potential Moderating Effects of Inhibitory Control |
| title_sort | neural correlates of irritability and potential moderating effects of inhibitory control |
| topic | Cognitive control Inhibitory control Irritability Network-based analyses Reward processing Threat processing |
| url | http://www.sciencedirect.com/science/article/pii/S2667174324001332 |
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